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Comparative study of histological features between core needle biopsy and surgical excision in phyllodes tumor

Authors
 Junjeong Choi  ;  Ja Seung Koo 
Citation
 Pathology International, Vol.62(2) : 120-126, 2012 
Journal Title
 Pathology International 
ISSN
 1320-5463 
Issue Date
2012
Abstract
We analyzed histopathological features of core needle biopsy (CNB) and surgical excision specimen comparatively in 129 patients with surgically proven phyllodes tumor (PT). Stromal characteristics including cellularity, atypia, mitosis, overgrowth, tissue fragmentation, and the tumor margin were assessed. Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8%)/30 (23.3%)/9 (7.0%) patients. Among the 90 cases of benign PTs, 67 cases (74.4%) were diagnosed concordantly in CNB. For borderline and malignant PTs, three out of eight (26.6%) and four out of nine (44.4%) cases were diagnosed concordantly in CNBs. All 50 cases of discordant diagnosis were underestimated in matched CNBs, especially in their stromal cellularity and mitosis. The size of tumor is larger in discordant cases of PT (P= 0.013). The concordant rate of diagnosis between CNB and surgical excision was about 60% and accordingly, grading of PT based on the histological findings in CNBs has limitation. The discordance comes from heterogeneous stromal properties of PTs.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91641
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1827.2011.02761.x/abstract
DOI
10.1111/j.1440-1827.2011.02761.x
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
구자승(Koo, Ja Seung) ORCID logo https://orcid.org/0000-0003-4546-4709
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