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Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption

DC FieldValueLanguage
dc.contributor.author황영선-
dc.contributor.author박광균-
dc.contributor.author이선경-
dc.contributor.author정원윤-
dc.date.accessioned2014-12-19T17:32:33Z-
dc.date.available2014-12-19T17:32:33Z-
dc.date.issued2012-
dc.identifier.issn1368-8375-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91603-
dc.description.abstractLysophosphatidic acid (LPA) is a bioactive lipid with a growth factor-like activity on a large range of cell types. Several pieces of evidence raise the possibility that LPA may play an important role in bone metastasis. Bone is a frequent metastatic site for oral cancer. However, the role of LPA in the progression of oral cancer metastasis to the bone is poorly understood. Here, we provide evidence for the role of LPA in the progression of oral cancer bone metastases and its regulatory mechanism. LPA induced the secretion of IL-6 and IL-8 in oral squamous cell carcinoma (OSCC). LPA-stimulated secretion of IL-6 and IL-8 is partly dependent on the LPA and EGF receptor (EGFR) pathways. ERK1/2 and Akt-mediated NF-κB and AP-1 were responsible for the LPA-induced IL-6 and IL-8 secretion. Moreover, conditioned medium (CM) derived from the LPA-stimulated OSCC supported osteoclast formation in bone marrow-derived macrophages (BMMs). Neutralization against both human IL-6 and IL-8 suppressed osteoclast formation induced by CM derived from the LPA-stimulated OSCC. Direct treatment with recombinant IL-6 (rIL-6) and/or soluble IL-6 receptor (sIL-6R), or IL-8 (rIL-8) reproduced the effect of the CM derived from the LPA-stimulated OSCC on osteoclast formation. In addition, CM derived from the LPA-stimulated OSCC induced receptor activator of nuclear factor (NF)-κB ligand (RANKL) expression in human osteoblasts and direct treatment with rIL-6 and/or sIL-6R or rIL-8 mimicked the effect of the CM derived from the LPA-stimulated OSCC for RANKL expression. Taken together, LPA may be a potent inducer of osteolytic factor IL-6 and IL-8 in OSCC. LPA-induced IL-6 and IL-8 exerted propound effects on RANKL expression in osteoblast and thereby promoted osteoclast formation from osteoclast precursors.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfOral Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSecretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Cancer Research Institute (구강종양연구소)-
dc.contributor.googleauthorYoung Sun Hwang-
dc.contributor.googleauthorSun Kyoung Lee-
dc.contributor.googleauthorKwang-Kyun Park-
dc.contributor.googleauthorWon-Yoon Chung-
dc.identifier.doi10.1016/j.oraloncology.2011.08.022-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04472-
dc.contributor.localIdA01429-
dc.contributor.localIdA02854-
dc.contributor.localIdA03676-
dc.relation.journalcodeJ02440-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1368837511008116-
dc.contributor.alternativeNameHwang, Young Sun-
dc.contributor.alternativeNamePark, Kwang Kyun-
dc.contributor.alternativeNameLee, Seon Kyung-
dc.contributor.alternativeNameChung, Won Yoon-
dc.contributor.affiliatedAuthorHwang, Young Sun-
dc.contributor.affiliatedAuthorPark, Kwang Kyun-
dc.contributor.affiliatedAuthorLee, Seon Kyung-
dc.contributor.affiliatedAuthorChung, Won Yoon-
dc.identifier.localIdT201200102-
dc.citation.volume48-
dc.citation.number1-
dc.citation.startPage40-
dc.citation.endPage48-
dc.identifier.bibliographicCitationOral Oncology, Vol.48(1) : 40-48, 2012-
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)

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