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Cited 6 times in

Body fluid MMP-2 as a putative biomarker in metastatic breast cancer

DC FieldValueLanguage
dc.contributor.author김기향-
dc.contributor.author노세원-
dc.contributor.author라선영-
dc.contributor.author이하영-
dc.contributor.author정민규-
dc.contributor.author정재준-
dc.contributor.author정희철-
dc.date.accessioned2014-12-19T17:32:05Z-
dc.date.available2014-12-19T17:32:05Z-
dc.date.issued2012-
dc.identifier.issn1792-1074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91588-
dc.description.abstractIn the present study, we investigated the role of matrix metalloproteinase (MMP)-2 and -9 as novel biomarkers in the body fluid of patients with metastatic breast cancer. We measured the expression of MMPs in 37 samples of body fluid (10 peritoneal and 27 pleural fluids) from metastatic breast cancer patients between 2000 and 2009. Zymography and ELISA assays were used to determine the cut-off level and to quantify MMP expression from a positive control, HT-1080 conditioned media. MMP expression in patient samples was measured with ELISA and compared with other clinical parameters. Ascitic carcinoembryonic antigen (CEA) and pleural CEA were measured in patient samples with a chemiluminescent enzyme immunoassay. Body fluid cytology had a positivity of 45% (9/20) for pleural fluid and 28.6% (2/7) for ascites. However, MMP-2 had a positivity of 85.2% (23/27) in 27 pleural fluid samples and 100% (10/10) in ascitic fluid with cut-off levels of 8.6 and 0.14 ng/ml for MMP-2 and -9, respectively. When body fluid CEA and MMP-2 were combined, the positivity improved to 96% in pleural fluid and 100% in ascites. MMP-2 expression in body fluid did not show any significant differences, but MMP-9 expression was lower in ascites than in pleural fluids (p<0.005). Our results suggest that MMP-2 expression in body fluid be used as an additive diagnostic marker for metastatic breast cancer patients.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfOncology Letters-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleBody fluid MMP-2 as a putative biomarker in metastatic breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSEWON NOH-
dc.contributor.googleauthorJAE-JOON JUNG-
dc.contributor.googleauthorMINKYU JUNG-
dc.contributor.googleauthorKI-HYANG KIM-
dc.contributor.googleauthorHA‑YOUNG-
dc.contributor.googleauthorBRANDON WANG-
dc.contributor.googleauthorJOANNA CHO-
dc.contributor.googleauthorTAE SOO KIM-
dc.contributor.googleauthorHEI‑CHEUL JEUNG-
dc.contributor.googleauthorSUN YOUNG RHA-
dc.identifier.doi10.3892/ol.2012.549-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00342-
dc.contributor.localIdA01282-
dc.contributor.localIdA03271-
dc.contributor.localIdA03606-
dc.contributor.localIdA03794-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ02417-
dc.contributor.alternativeNameKim, Ki Hyang-
dc.contributor.alternativeNameNoh, Se Won-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameLee, Ha Young-
dc.contributor.alternativeNameJung, Min Kyu-
dc.contributor.alternativeNameJung, Jae Joon-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.affiliatedAuthorKim, Ki Hyang-
dc.contributor.affiliatedAuthorNoh, Se Won-
dc.contributor.affiliatedAuthorLee, Ha Young-
dc.contributor.affiliatedAuthorJung, Min Kyu-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.citation.volume3-
dc.citation.number3-
dc.citation.startPage699-
dc.citation.endPage703-
dc.identifier.bibliographicCitationOncology Letters, Vol.3(3) : 699-703, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers

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