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Inhibition of IGF-1 signaling by genistein: modulation of E-cadherin expression and downregulation of β-catenin signaling in hormone refractory PC-3 prostate cancer cells
DC Field | Value | Language |
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dc.contributor.author | 이주민 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2014-12-19T17:31:36Z | - |
dc.date.available | 2014-12-19T17:31:36Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0163-5581 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91574 | - |
dc.description.abstract | Elevated levels of insulin-like growth factor-1 (IGF-1) are associated with an increased risk of several different cancers, including prostate cancer. Inhibition of IGF-1 and the downstream signaling pathways mediated by the activation of the IGF-1 receptor (IGF-1R) may be involved in inhibiting prostate carcinogenesis. We investigated whether genistein downregulated the IGF-1/IGF-1R signaling pathway and inhibited cell growth in hormone refractory PC-3 prostate cancer cells. Genistein treatment caused a significant inhibition of IGF-1-stimulated cell growth. Flow cytometry analysis revealed that genistein significantly decreased the number of IGF-1-stimulated cells in the G0/G1 phase of the cell cycle. In IGF-1-treated cells, genistein effectively inhibited the phosphorylation of IGF-1R and the phosphorylation of its downstream targets, such as Src, Akt, and glycogen synthase kinase-3β (GSk-3β). IGF-1 treatment decreased the levels of E-cadherin but increased the levels of β-catenin and cyclin D1. However, genistein treatment greatly attenuated IGF-1-induced β-catenin signaling that correlated with increasing the levels of E-cadherin and decreasing cyclin D1 levels in PC-3 cells. In addition, genistein inhibited T-cell factor/lymphoid enhancer factor (TCF/LEF)-dependent transcriptional activity. These results showed that genistein effectively inhibited cell growth in IGF-1-stimulated PC-3 cells, possibly by inhibiting downstream of IGF-1R activation. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cadherins/metabolism* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Down-Regulation/drug effects | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/drug effects | - |
dc.subject.MESH | Genistein/pharmacology* | - |
dc.subject.MESH | Glycogen Synthase Kinase 3/metabolism | - |
dc.subject.MESH | Glycogen Synthase Kinase 3 beta | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin-Like Growth Factor I/metabolism* | - |
dc.subject.MESH | Insulin-Like Growth Factor I/pharmacology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mitogen-Activated Protein Kinase 1/metabolism | - |
dc.subject.MESH | Mitogen-Activated Protein Kinase 3/metabolism | - |
dc.subject.MESH | Phosphorylation/drug effects | - |
dc.subject.MESH | Prostatic Neoplasms/drug therapy* | - |
dc.subject.MESH | Prostatic Neoplasms/metabolism* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.MESH | Proto-Oncogene Proteins pp60(c-src)/metabolism | - |
dc.subject.MESH | Receptor, IGF Type 1/metabolism | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Tyrosine/metabolism | - |
dc.subject.MESH | beta Catenin/metabolism* | - |
dc.title | Inhibition of IGF-1 signaling by genistein: modulation of E-cadherin expression and downregulation of β-catenin signaling in hormone refractory PC-3 prostate cancer cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Joomin Lee | - |
dc.contributor.googleauthor | Jihyeung Ju | - |
dc.contributor.googleauthor | Seyeon Park | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Sun Yoon | - |
dc.identifier.doi | 22098108 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03158 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02399 | - |
dc.identifier.eissn | 1532-7914 | - |
dc.identifier.pmid | 22098108 | - |
dc.identifier.url | http://www.tandfonline.com/doi/abs/10.1080/01635581.2012.630161 | - |
dc.subject.keyword | Cadherins/metabolism* | - |
dc.subject.keyword | Cell Line, Tumor | - |
dc.subject.keyword | Cell Proliferation/drug effects | - |
dc.subject.keyword | Down-Regulation/drug effects | - |
dc.subject.keyword | Gene Expression Regulation, Neoplastic/drug effects | - |
dc.subject.keyword | Genistein/pharmacology* | - |
dc.subject.keyword | Glycogen Synthase Kinase 3/metabolism | - |
dc.subject.keyword | Glycogen Synthase Kinase 3 beta | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Insulin-Like Growth Factor I/metabolism* | - |
dc.subject.keyword | Insulin-Like Growth Factor I/pharmacology | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Mitogen-Activated Protein Kinase 1/metabolism | - |
dc.subject.keyword | Mitogen-Activated Protein Kinase 3/metabolism | - |
dc.subject.keyword | Phosphorylation/drug effects | - |
dc.subject.keyword | Prostatic Neoplasms/drug therapy* | - |
dc.subject.keyword | Prostatic Neoplasms/metabolism* | - |
dc.subject.keyword | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.keyword | Proto-Oncogene Proteins pp60(c-src)/metabolism | - |
dc.subject.keyword | Receptor, IGF Type 1/metabolism | - |
dc.subject.keyword | Signal Transduction/drug effects | - |
dc.subject.keyword | Tyrosine/metabolism | - |
dc.subject.keyword | beta Catenin/metabolism* | - |
dc.contributor.alternativeName | Lee, Joo Min | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Lee, Joo Min | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.citation.volume | 64 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 153 | - |
dc.citation.endPage | 162 | - |
dc.identifier.bibliographicCitation | NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, Vol.64(1) : 153-162, 2012 | - |
dc.identifier.rimsid | 29314 | - |
dc.type.rims | ART | - |
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