4 284

Cited 0 times in

Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress

DC FieldValueLanguage
dc.contributor.author김동구-
dc.contributor.author김철훈-
dc.contributor.author임영신-
dc.date.accessioned2014-12-19T17:30:49Z-
dc.date.available2014-12-19T17:30:49Z-
dc.date.issued2012-
dc.identifier.issn0304-3940-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91549-
dc.description.abstractAn individual's behavior is generally based on genetic blueprint and previous experiences. A coping strategy, affected by personal interpretation of past events, can be determined by behavioral controllability of stress. In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress. Rats were exposed to stress via inescapable and unpredictable footshocks on PNDs 14 and 90. Coping strategies to stress were also measured. Hippocampal mGluR5 was found to be linked to the behavioral coping strategy, as it increased in rats that showed helplessness behavior (HL (+) group) and decreased in those that did not (HL (-) group). Also, the HL (+) group showed a lack of adaptation in a novel environment but the HL (-) group did not. The results suggest that mGluR5 has a pivotal role in the controllability-based coping strategy. Hippocampal mGluR5 could be a target molecule in the manipulation of neuropsychiatric conditions for which maladaptation is a part of behavioral consequences.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNEUROSCIENCE LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdaptation, Psychological*-
dc.subject.MESHAnimals-
dc.subject.MESHBiomarkers/metabolism-
dc.subject.MESHChronic Disease-
dc.subject.MESHHelplessness, Learned*-
dc.subject.MESHHippocampus/metabolism*-
dc.subject.MESHRats-
dc.subject.MESHReceptor, Metabotropic Glutamate 5-
dc.subject.MESHReceptors, Metabotropic Glutamate/metabolism*-
dc.subject.MESHStress, Psychological/metabolism*-
dc.titleHippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorYeong Shin Yim-
dc.contributor.googleauthorJinu Lee-
dc.contributor.googleauthorGun-Tae Kim-
dc.contributor.googleauthorTeresa Song-
dc.contributor.googleauthorChul Hoon Kim-
dc.contributor.googleauthorDong Goo Kim-
dc.identifier.doi22617006-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00396-
dc.contributor.localIdA01057-
dc.contributor.localIdA03385-
dc.relation.journalcodeJ02364-
dc.identifier.eissn1872-7972-
dc.identifier.pmid22617006-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304394012006581-
dc.subject.keywordmGluR5-
dc.subject.keywordHelplessness-
dc.subject.keywordCoping strategy-
dc.subject.keywordStress-
dc.subject.keywordRat-
dc.contributor.alternativeNameKim, Dong Goo-
dc.contributor.alternativeNameKim, Chul Hoon-
dc.contributor.alternativeNameYim, Yeong Shin-
dc.contributor.affiliatedAuthorKim, Dong Goo-
dc.contributor.affiliatedAuthorKim, Chul Hoon-
dc.contributor.affiliatedAuthorYim, Yeong Shin-
dc.citation.volume519-
dc.citation.number1-
dc.citation.startPage62-
dc.citation.endPage66-
dc.identifier.bibliographicCitationNEUROSCIENCE LETTERS, Vol.519(1) : 62-66, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.