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Regional brain metabolism and treatment response in panic disorder patients: an [18F]FDG-PET study

Authors
 Kang E.-H.  ;  Park J.-E.  ;  Lee K.-H.  ;  Cho Y.-S.  ;  Kim J.-J.  ;  Yu B.-H. 
Citation
 NEUROPSYCHOBIOLOGY, Vol.66(2) : 106-111, 2012 
Journal Title
 NEUROPSYCHOBIOLOGY 
ISSN
 0302-282X 
Issue Date
2012
MeSH
Adult ; Brain/drug effects ; Brain/metabolism* ; Case-Control Studies ; Citalopram/therapeutic use* ; Female ; Fluorodeoxyglucose F18 ; Frontal Lobe/drug effects ; Frontal Lobe/metabolism ; Glucose/metabolism* ; Gyrus Cinguli/drug effects ; Gyrus Cinguli/metabolism ; Humans ; Limbic System/drug effects ; Limbic System/metabolism ; Male ; Middle Aged ; Neocortex/drug effects ; Neocortex/metabolism ; Panic Disorder/diagnostic imaging ; Panic Disorder/drug therapy ; Panic Disorder/metabolism* ; Positron-Emission Tomography ; Radiopharmaceuticals ; Serotonin Uptake Inhibitors/therapeutic use* ; Temporal Lobe/drug effects ; Temporal Lobe/metabolism ; Treatment Outcome
Keywords
Escitalopram ; Treatment response ; Fluorodeoxyglucose-PET ; Neocortical function ; Panic disorder ; Selective serotonin reuptake inhibitors
Abstract
BACKGROUND: Panic disorder (PD) is a common and often chronic psychiatric condition that can lead to considerable disability in daily life. Using [(18)F]fluorodeoxyglucose-PET, we examined brain baseline glucose metabolism in PD patients in comparison with normal controls and the changes in glucose metabolism after 12 weeks of escitalopram treatment. METHODS: Fifteen patients with PD were compared to 20 normal controls using [(18)F]FDG-PET at baseline and brain metabolism after 12 weeks of escitalopram treatment was compared to pretreatment in the patient group using voxel-based statistical analysis and post hoc region-of-interest analysis. RESULTS: Patients with PD showed decreased metabolism in both the frontal, right temporal, and left posterior cingulate gyruses. After 12 weeks of escitalopram treatment, treatment responders showed metabolic increases in global neocortical areas as well as limbic areas whereas nonresponders did not. CONCLUSION: Abnormal neocortical function appears to be associated with the pathophysiology of PD and escitalopram exerts its therapeutic action by modulating brain activity at the level of the neocortex and limbic system, notably the amygdala and parahippocampal gyrus.
Full Text
http://www.karger.com/Article/FullText/337740
DOI
22814210
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91536
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