2 267

Cited 0 times in

Thalamocortical inputs show post-critical-period plasticity

Authors
 Xin Yu  ;  Seungsoo Chung  ;  Der-Yow Chen  ;  Shumin Wang  ;  Stephen J. Dodd  ;  Judith R. Walters  ;  John T.R. Isaac  ;  Alan P. Koretsky 
Citation
 NEURON, Vol.74(4) : 731-742, 2012 
Journal Title
 NEURON 
ISSN
 0896-6273 
Issue Date
2012
MeSH
Animals ; Critical Period (Psychology) ; Excitatory Postsynaptic Potentials/physiology ; Magnetic Resonance Imaging ; Neural Pathways/physiology ; Neuronal Plasticity/physiology* ; Rats ; Rats, Sprague-Dawley ; Somatosensory Cortex/physiology* ; Synapses/physiology ; Thalamus/physiology*
Keywords
Animals ; Critical Period (Psychology) ; Excitatory Postsynaptic Potentials/physiology ; Magnetic Resonance Imaging ; Neural Pathways/physiology ; Neuronal Plasticity/physiology* ; Rats ; Rats, Sprague-Dawley ; Somatosensory Cortex/physiology* ; Synapses/physiology ; Thalamus/physiology*
Abstract
Experience-dependent plasticity in the adult brain has clinical potential for functional rehabilitation following central and peripheral nerve injuries. Here, plasticity induced by unilateral infraorbital (IO) nerve resection in 4-week-old rats was mapped using MRI and synaptic mechanisms were elucidated by slice electrophysiology. Functional MRI demonstrates a cortical potentiation compared to thalamus 2 weeks after IO nerve resection. Tracing thalamocortical (TC) projections with manganese-enhanced MRI revealed circuit changes in the spared layer 4 (L4) barrel cortex. Brain slice electrophysiology revealed TC input strengthening onto L4 stellate cells due to an increase in postsynaptic strength and the number of functional synapses. This work shows that the TC input is a site for robust plasticity after the end of the previously defined critical period for this input. Thus, TC inputs may represent a major site for adult plasticity in contrast to the consensus that adult plasticity mainly occurs at cortico-cortical connections.
Full Text
http://www.sciencedirect.com/science/article/pii/S0896627312003923
DOI
22632730
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Chung, Seung Soo(정승수) ORCID logo https://orcid.org/0000-0002-3119-9628
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91534
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links