134 226

Cited 0 times in

Surfactant lavage therapy for meconium aspiration syndrome: a systematic review and meta-analysis

 Hyun Jin Choi  ;  Seokyung Hahn  ;  Joongyub Lee  ;  Byung-Joo Park  ;  Soon Min Lee  ;  Han-Suk Kim  ;  Chong-Woo Bae 
 NEONATOLOGY, Vol.101(3) : 183-191, 2012 
Journal Title
Issue Date
Biological Products/administration & dosage ; Biological Products/therapeutic use* ; Bronchoalveolar Lavage/methods* ; Drug Combinations ; Fatty Alcohols/administration & dosage ; Fatty Alcohols/therapeutic use* ; Humans ; Infant, Newborn ; Meconium Aspiration Syndrome/drug therapy* ; Meconium Aspiration Syndrome/mortality ; Phosphatidylglycerols/administration & dosage ; Phosphatidylglycerols/therapeutic use* ; Proteins/administration & dosage ; Proteins/therapeutic use* ; Pulmonary Surfactants/administration & dosage ; Pulmonary Surfactants/therapeutic use* ; Randomized Controlled Trials as Topic ; Survival Rate ; Treatment Outcome
Meconium ; Meconium aspiration syndrome ; Surfactant ; Pulmonary surfactant ; Bronchoalveolar lavage ; Neonate
BACKGROUND: Lung lavage with diluted surfactant has emerged as an innovative treatment for meconium aspiration syndrome (MAS). However, the treatment effect has not yet been fully established. OBJECTIVE: To investigate the effects of surfactant lavage therapy for MAS by a systematic meta-analysis. METHODS: Relevant studies were identified by database searches in MEDLINE (from 1950), EMBASE (from 1980), and CENTRAL, up to June 2010, and by additional hand searches. Meta-analyses were separately conducted for randomized controlled trials (RCTs) and non-randomized controlled studies (NRSs). Risk of bias was assessed and clinical as well as statistical heterogeneities were also investigated in explaining the potential bias. RESULTS: Two RCTs (87 patients) and eight NRSs (178 patients) were identified. From the results of the meta-analysis of RCTs, surfactant lavage significantly decreased death or the need for extracorporeal membrane oxygenation (RR 0.34, 95% CI 0.11, 0.99). An interventional benefit was indicated for other outcomes, although it was not statistically significant based only on the two RCTs. Results from the analysis of outcomes from NRSs are consistent with those from RCTs and demonstrated a beneficial effect, which could be considered as supporting evidence. CONCLUSIONS: Lung lavage with diluted surfactant appeared to improve the clinical outcome in infants with MAS. Given that less than 100 infants were included in the two RCTs, the findings of this study may still be regarded as insufficient evidence. Further research will be needed to confirm the benefit as well as to refine the lavage technique.
Files in This Item:
T201200468.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Soon Min(이순민) ORCID logo https://orcid.org/0000-0003-0174-1065
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.