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The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer.

DC FieldValueLanguage
dc.contributor.author박수빈-
dc.contributor.author박승우-
dc.contributor.author박정엽-
dc.contributor.author방승민-
dc.contributor.author송시영-
dc.contributor.author정재복-
dc.date.accessioned2014-12-19T17:28:30Z-
dc.date.available2014-12-19T17:28:30Z-
dc.date.issued2012-
dc.identifier.issn1791-2997-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91476-
dc.description.abstractSonic hedgehog (SHh) signaling is essential for normal development of the human gastrointestinal (GI) tract and is reported to be aberrantly activated in GI cancers. However, the association between SHh signaling and extrahepatic biliary tract cancer is not clearly understood. In this study, we evaluated the activities of SHh family proteins and their downstream signals in extrahepatic biliary tract cancer. The activity of the SHh pathway was analyzed in established human extrahepatic biliary tract cell lines and human cancer tissues using RT-PCR and immunohistochemistry. We also evaluated the effects of suppressing the SHh pathway with cyclopamine and siRNA. The SHh, Smo and Gli-1 genes were overexpressed in extrahepatic biliary tract cancer cell lines and six extrahepatic biliary tract cancer tissues compared to the levels in normal biliary tract tissues. The degrees of SHh and Gli-1 expression were independent of tumor stage and cancer cell differentiation. SHh pathway suppression with cyclopamine or siRNA inhibited proliferation of extrahepatic biliary tract cancer cell lines. In conclusion, the SHh pathway is highly activated in extrahepatic biliary tract cancer and is a potential anticancer drug target.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfMOLECULAR MEDICINE REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBile Ducts, Extrahepatic*-
dc.subject.MESHBiliary Tract Neoplasms/metabolism*-
dc.subject.MESHBiliary Tract Neoplasms/pathology-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Proliferation-
dc.subject.MESHFemale-
dc.subject.MESHHedgehog Proteins/antagonists & inhibitors*-
dc.subject.MESHHedgehog Proteins/genetics-
dc.subject.MESHHedgehog Proteins/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHRNA Interference-
dc.subject.MESHRNA, Small Interfering/metabolism-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSignal Transduction-
dc.subject.MESHTranscription Factors/metabolism-
dc.subject.MESHVeratrum Alkaloids/pharmacology-
dc.subject.MESHZinc Finger Protein GLI1-
dc.titleThe sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorYoon Jae Kim-
dc.contributor.googleauthorSoo Bin Park-
dc.contributor.googleauthorJeong Youp Park-
dc.contributor.googleauthorSeung Woo Park-
dc.contributor.googleauthorJae Bock Chung-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorSeungmin Bang-
dc.identifier.doi21946948-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01533-
dc.contributor.localIdA01551-
dc.contributor.localIdA01647-
dc.contributor.localIdA01786-
dc.contributor.localIdA02035-
dc.contributor.localIdA03706-
dc.relation.journalcodeJ02261-
dc.identifier.eissn1791-3004-
dc.identifier.pmid21946948-
dc.identifier.urlhttp://www.spandidos-publications.com/mmr/5/1/12-
dc.subject.keywordAged-
dc.subject.keywordBile Ducts, Extrahepatic*-
dc.subject.keywordBiliary Tract Neoplasms/metabolism*-
dc.subject.keywordBiliary Tract Neoplasms/pathology-
dc.subject.keywordCell Line, Tumor-
dc.subject.keywordCell Proliferation-
dc.subject.keywordFemale-
dc.subject.keywordHedgehog Proteins/antagonists & inhibitors*-
dc.subject.keywordHedgehog Proteins/genetics-
dc.subject.keywordHedgehog Proteins/metabolism-
dc.subject.keywordHumans-
dc.subject.keywordImmunohistochemistry-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordNeoplasm Staging-
dc.subject.keywordRNA Interference-
dc.subject.keywordRNA, Small Interfering/metabolism-
dc.subject.keywordReverse Transcriptase Polymerase Chain Reaction-
dc.subject.keywordSignal Transduction-
dc.subject.keywordTranscription Factors/metabolism-
dc.subject.keywordVeratrum Alkaloids/pharmacology-
dc.subject.keywordZinc Finger Protein GLI1-
dc.contributor.alternativeNamePark, Soo Bin-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.alternativeNamePark, Jeong Youp-
dc.contributor.alternativeNameBang, Seung Min-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameChung, Jae Bock-
dc.contributor.affiliatedAuthorPark, Soo Bin-
dc.contributor.affiliatedAuthorPark, Seung Woo-
dc.contributor.affiliatedAuthorPark, Jeong Youp-
dc.contributor.affiliatedAuthorBang, Seung Min-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorChung, Jae Bock-
dc.citation.volume5-
dc.citation.number1-
dc.citation.startPage12-
dc.citation.endPage16-
dc.identifier.bibliographicCitationMOLECULAR MEDICINE REPORTS, Vol.5(1) : 12-16, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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