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Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial.

 Kim, Sun Young  ;  Seo, Seok Kyo  ;  Choi, Young Mi  ;  Jeon, Young Eun  ;  Lim, Kyung Jin  ;  Cho, SiHyun  ;  Choi, Young Sik  ;  Lee, Byung Seok 
 Menopause - the Journal of the North American Menopause Society, Vol.19(4) : 461-466, 2012 
Journal Title
 Menopause - the Journal of the North American Menopause Society 
Issue Date
OBJECTIVE: The aim of this study was to evaluate the effects of red ginseng (RG) on menopausal symptoms and cardiovascular risk factors in postmenopausal women. METHODS: A randomized, placebo-controlled, double-blind clinical trial was conducted with postmenopausal women between the ages of 45 and 60 years. A total of 72 women were randomly assigned to either an RG group (supplemented with 3 g of RG, including 60 mg of ginsenosides, per day) or a placebo group for 12 weeks. We analyzed changes in menopausal symptoms (the Kupperman index and the menopause rating scale), cardiovascular risk factors (lipid profiles, high-sensitivity C-reactive protein, and carotid intima-media thickness), and serum estradiol levels from baseline to 12 weeks. RESULTS: Significant improvements in the Kupperman index (P = 0.032) and in the menopause rating scale (P = 0.035) scores were observed in the RG group compared with the placebo group. Total cholesterol (P = 0.009) and low-density lipoprotein cholesterol (P = 0.015) significantly decreased in the group receiving RG. The RG group also showed a significant decrease in carotid intima-media thickness (P = 0.049). Serum estradiol levels were not influenced by RG supplementation. CONCLUSIONS: RG could be an attractive herbal dietary supplement for relieving menopausal symptoms and conferring favorable effects on markers of cardiovascular disease in postmenopausal women.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실)
Yonsei Authors
김선영(Kim, Seon Young) ; 서석교(Seo, Seok Kyo) ; 이병석(Lee, Byung Seok) ; 임경진(Lim, Kyung Jin) ; 전영은(Jeon, Young Eun) ; 조시현(Cho, Si Hyun) ; 최영미(Choi, Young Mi) ; 최영식(Choi, Young Sik)
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