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Relationships between serum uric acid, adiponectin and arterial stiffness in postmenopausal women.

 Jong Suk Park  ;  Shinae Kang  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Kyung Rae Kim  ;  Hyun Chul Lee 
 MATURITAS, Vol.73(4) : 344-348, 2012 
Journal Title
Issue Date
Adiponectin/blood* ; Blood Glucose/metabolism ; Body Mass Index ; Cardiovascular Diseases/blood* ; Cholesterol/blood ; Female ; Humans ; Insulin Resistance ; Middle Aged ; Multivariate Analysis ; Postmenopause ; Pulse Wave Analysis ; Regression Analysis ; Triglycerides/blood ; Uric Acid/blood* ; Vascular Stiffness/physiology* ; Waist Circumference/physiology
Uric acid ; Adiponectin ; Pulse wave velocity ; Menopause
OBJECTIVES: Cardiovascular disease (CVD) is a leading cause of death in postmenopausal women. Elevated serum uric acid levels, hypoadiponectinemia and arterial stiffness are strongly associated with cardiovascular diseases. We investigated the relationships among uric acid, adiponectin and arterial stiffness in postmenopausal women. STUDY DESIGN: 9555 subjects who had the routine health check-ups, 841 postmenopausal women aged 50 years or older who had not had a menstrual period for more than 12 consecutive months were included in this study. MAIN OUTCOME MEASURES: BMI, WC, and serum concentrations of uric acid, adiponectin, glucose, lipids (total cholesterol, triglycerides, LDL cholesterol, and HDL cholesterol) were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Pulse wave velocity (PWV) was evaluated to assess arterial stiffness. RESULTS: The subjects were stratified into three groups according to uric acid values. PWV values gradually increased and adiponectin level decreased with uric acid tertiles. Serum uric acid levels in postmenopausal women correlated significantly with age, BMI, WC, TG, HDL-C, insulin, HOMA-IR, adiponectin and PWV. Multiple regression analysis showed that WC (β=0.141, P<0.01), HOMA (β=0.137, P<0.01), adiponectin (β=-0.104, P<0.01), and PWV (β=0.129, P<0.01) were independently correlated with uric acid levels. In multiple logistic regression analysis after adjusting for risk factors, uric acid was a significant contributor to increased PWV. CONCLUSIONS: These findings indicate that serum uric acid is independently associated with adiponectin and arterial stiffness in postmenopausal women.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Ae(강신애) ORCID logo https://orcid.org/0000-0002-9719-4774
Kim, Kyung Rae(김경래)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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