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Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population.

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dc.contributor.author김승원-
dc.contributor.author김원호-
dc.contributor.author김은수-
dc.contributor.author김태일-
dc.contributor.author문창모-
dc.contributor.author박재준-
dc.contributor.author천재희-
dc.date.accessioned2014-12-19T17:26:09Z-
dc.date.available2014-12-19T17:26:09Z-
dc.date.issued2012-
dc.identifier.issn0024-3205-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91403-
dc.description.abstractAIMS: Although polymorphisms in IL23R have recently been proposed to predispose to Behcet's disease (BD), associations between IL23R polymorphisms and intestinal BD have yet to be elucidated. We therefore performed a study to evaluate whether IL17A, IL23R, and STAT4 polymorphisms are associated with susceptibility to intestinal BD in the Korean population. MAIN METHODS: Single nucleotide polymorphisms (SNP) in the IL17A, IL23R, and STAT4 genes were analyzed using DNA sequencing, denaturing high performance liquid chromatography, and TaqMan genotyping assays. KEY FINDINGS: Individual polymorphism analysis revealed that the TT genotype of IL17A rs8193036 (odds ratio (OR) 2.10, 95% confidence interval (CI) (1.12-3.92), p=0.021), and GG+GT genotype of IL23R rs1884444 (OR 1.92, 95% CI (1.03-3.57), p=0.034) was associated with the development of intestinal BD. When these two genotypes were combined, the risk of BD increased compared to that of patients with no-risk or one-risk genotype (OR 2.21, 95% CI (1.13-4.34), p=0.021). Furthermore, statistically significant gene-gene interactions were observed between G149R in IL23R vs. rs11685878 in STAT4, rs2275913 in IL17A vs. rs7574865 in STAT4, and rs11889341 in STAT4 vs. rs2275913 in IL17A. The haplotypes of IL17A had a positive association with intestinal BD risks, whereas those of IL23R were protective for disease development. SIGNIFICANCE: Our results indicate that the interaction of specific IL17A, IL23R, and STAT4 SNPs modulate susceptibility to intestinal BD in the Korean population, suggesting that the IL-17/23 axis plays a significant role in disease pathogenesis.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfLIFE SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHBehcet Syndrome/epidemiology-
dc.subject.MESHBehcet Syndrome/genetics*-
dc.subject.MESHBehcet Syndrome/pathology-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Predisposition to Disease/genetics-
dc.subject.MESHGenome-Wide Association Study-
dc.subject.MESHHaplotypes-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-17/genetics*-
dc.subject.MESHIntestinal Diseases/epidemiology-
dc.subject.MESHIntestinal Diseases/genetics*-
dc.subject.MESHIntestinal Diseases/pathology-
dc.subject.MESHKorea/epidemiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNucleic Acid Amplification Techniques-
dc.subject.MESHPhenotype-
dc.subject.MESHPolymorphism, Genetic/genetics-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHReceptors, Interleukin/genetics*-
dc.subject.MESHRisk-
dc.subject.MESHSTAT4 Transcription Factor/genetics*-
dc.titleInteractions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorEun Soo Kim-
dc.contributor.googleauthorSeung Won Kim-
dc.contributor.googleauthorChang Mo Moon-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.identifier.doi22483685-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA01390-
dc.contributor.localIdA01636-
dc.contributor.localIdA04030-
dc.contributor.localIdA00804-
dc.contributor.localIdA00656-
dc.relation.journalcodeJ02167-
dc.identifier.eissn1879-0631-
dc.identifier.pmid22483685-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0024320512001403-
dc.subject.keywordBehcet's disease-
dc.subject.keywordIL17A-
dc.subject.keywordIL23R-
dc.subject.keywordSTAT4-
dc.subject.keywordPolymorphism-
dc.contributor.alternativeNameKim, Seung Won-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Eun Soo-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNameMoon, Chang Mo-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorMoon, Chang Mo-
dc.contributor.affiliatedAuthorPark, Jae Jun-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.contributor.affiliatedAuthorKim, Eun Soo-
dc.contributor.affiliatedAuthorKim, Seung Won-
dc.citation.volume90-
dc.citation.number19-20-
dc.citation.startPage740-
dc.citation.endPage746-
dc.identifier.bibliographicCitationLIFE SCIENCES, Vol.90(19-20) : 740-746, 2012-
dc.identifier.rimsid31258-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers

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