4 199

Cited 14 times in

Capacitance-based assay for real-time monitoring of endocytosis and cell viability.

DC FieldValueLanguage
dc.contributor.author최인홍-
dc.contributor.author김숙영-
dc.contributor.author박승우-
dc.contributor.author신전수-
dc.date.accessioned2014-12-19T17:25:00Z-
dc.date.available2014-12-19T17:25:00Z-
dc.date.issued2012-
dc.identifier.issn1473-0197-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91367-
dc.description.abstractLabel-free cell-based assays have emerged as a promising means for high-throughput screening. Most label-free sensors are based on impedance measurements that reflect the passive electrical properties of cells. Here we introduce a capacitance-based assay that measures the dielectric constant (capacitance) of biological cells, and demonstrate the feasibility of analyzing endocytosis and screening chemotherapeutic agents with this assay. Endocytosis induces a change in the zeta potential, leading to a change in the dielectric constant which enables real-time endocytosis monitoring using the capacitance sensor. Additionally, since the dielectric constant is proportional to cell radius and cell volume, cell viability can be estimated from the change in capacitance. Therefore, the capacitance sensor array can also be used for cytotoxicity testing for large-scale chemotherapeutic screening.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfLab on a Chip-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCapacitance-based assay for real-time monitoring of endocytosis and cell viability.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학)-
dc.contributor.googleauthorRimi Lee-
dc.contributor.googleauthorJihun Kim-
dc.contributor.googleauthorSook Young Kim-
dc.contributor.googleauthorSeon Mi Jang-
dc.contributor.googleauthorSun-Mi Lee-
dc.contributor.googleauthorIn-Hong Choi-
dc.contributor.googleauthorSeung Woo Park-
dc.contributor.googleauthorJeon-Soo Shin-
dc.contributor.googleauthorKyung-Hwa Yoo-
dc.identifier.doi10.1039/C2LC21236F-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04167-
dc.contributor.localIdA00647-
dc.contributor.localIdA01551-
dc.contributor.localIdA02144-
dc.relation.journalcodeJ02148-
dc.identifier.urlhttp://pubs.rsc.org/en/Content/ArticleLanding/2012/LC/c2lc21236f-
dc.contributor.alternativeNameChoi, In Hong-
dc.contributor.alternativeNameKim, Sook Young-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.alternativeNameShin, Jeon Soo-
dc.contributor.affiliatedAuthorChoi, In Hong-
dc.contributor.affiliatedAuthorKim, Sook Young-
dc.contributor.affiliatedAuthorPark, Seung Woo-
dc.contributor.affiliatedAuthorShin, Jeon Soo-
dc.citation.volume12-
dc.citation.number13-
dc.citation.startPage2377-
dc.citation.endPage2384-
dc.identifier.bibliographicCitationLab on a Chip, Vol.12(13) : 2377-2384, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.