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Primary Mucinous Cystadenocarcinoma of the Breast: Cytologic Finding and Expression of MUC5 Are Different from Mucinous Carcinoma

Authors
 Sung Eun Kim ; Ji Hye Park ; Woo-Hee Jung ; Joon Jeong ; Ja Seung Koo ; SoonWon Hong 
Citation
 Korean Journal of Pathology, Vol.46(6) : 611~616, 2012 
Journal Title
 Korean Journal of Pathology 
ISSN
 1738-1843 
Issue Date
2012
Abstract
Mucinous cystadenocarcinoma (MCA) in the breast is a rare neoplasm. There have been 13 cases of primary breast MCA reported. The MCA presents as a large, partially cystic mass in postmenopausal woman with a good prognosis. The microscopic findings resemble those of ovarian, pancreatic, or appendiceal MCA. The aspiration findings showed mucin-containing cell clusters in the background of mucin and necrotic material. The cell clusters had intracytoplasmic mucin displacing atypical nuclei to the periphery. Histologically, the tumor revealed an abundant mucin pool with small floating clusters of mucin-containing tumor cells. There were also small cysts lined by a single layer of tall columnar mucinous cells, resembling those of the uterine endocervix. The cancer cells were positive for mucin (MUC) 5 and negative for MUC2 and MUC6. This mucin profile is different from ordinary mucinous carcinoma and may be a unique characteristic of breast MCA.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91321
DOI
10.4132/KoreanJPathol.2012.46.6.611
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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