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The clinicopathologic features of molecular apocrine breast cancer.

Authors
 Yoon Jin Cha ; Woo-Hee Jung ; Ja Seung Koo 
Citation
 Korean Journal of Pathology, Vol.46(2) : 169~176, 2012 
Journal Title
 Korean Journal of Pathology 
ISSN
 1738-1843 
Issue Date
2012
Abstract
BACKGROUND: To elucidate the clinicopathologic features and their implications on the immunohistochemistry in cases of molecular apocrine breast cancer (MABC). METHODS: Immunohistochemical (IHC) staining for estrogen receptor (ER), human epidermal growth factor receptor 2 (HER-2), cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), androgen receptor (AR), gamma-glutamyltrasferase 1 (GGT1) and Ki-67 was performed on tissue microarray breast cancer samples from 204 patients. Phenotypes of breast cancer were divided based on the IHC status of ER, AR and GGT1 into the following: luminal type, ER positive and AR and/or GGT1 positive; basal type, ER, AR, and GGT1 negative; non-basal type, ER positive and AR and GGT1 negative; and MABC type, ER negative and AR and/or GGT1 positive. RESULTS: In our series of patients (n=204), there were 26 cases of MABC. Besides, there were 18, 60, and 100 cases of luminal type, basal type and non-basal type, respectively. The MABC demonstrated apocrine histology and a higher prevalence of HER-2 positivity than other phenotypes. With the basal type, the MABC manifested a more frequent expression of CK5/6 and EGFR and a higher Ki-67 index than other phenotypes (p<0.001). There were no significant differences in patient prognosis between the phenotypes of breast cancer. CONCLUSIONS: MABC are distinguishable from other phenotypes based on the apocrine histology and a higher expression rate of HER-2.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91312
DOI
10.4132/KoreanJPathol.2012.46.2.169
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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