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Spontaneous non-traumatic stress fractures in bilateral femoral shafts in a patient treated with bisphosphonates

 Dong Yeob Shin  ;  Cheol Ryong Ku  ;  Kyung Min Kim  ;  Han Seok Choi  ;  Yumie Rhee  ;  Eun Jig Lee  ;  Sung-Kil Lim 
 Korean Journal of Internal Medicine, Vol.27(1) : 98-102, 2012 
Journal Title
 Korean Journal of Internal Medicine 
Issue Date
Bisphosphonates are potent inhibitors of bone resorption and widely used to treat osteoporosis. Extensive studies have shown that therapy with bisphosphonates improves bone density and decreases fracture risk. However, concerns have been raised about potential over-suppression of bone turnover during long-term use of bisphosphonates, resulting in increased susceptibility to and delayed healing of non-spinal fractures. We report a patient who sustained non-traumatic stress fractures in bilateral femoral shafts with delayed healing after long-term bisphosphonate therapy. She underwent open reduction and surgical internal fixation. Although bisphosphonates effectively prevent vertebral fractures, and their safety has been tested in randomized trials, we must emphasize the need for awareness of the possibility that long-term suppression of bone turnover with bisphosphonates may eventually lead to an accumulation of fatigue-induced damage and adverse skeletal effects such as delayed fracture healing.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
구철룡(Ku, Cheol Ryong) ORCID logo https://orcid.org/0000-0001-8693-9630
김경민(Kim, Kyung Min)
신동엽(Shin, Dong Yeob) ORCID logo https://orcid.org/0000-0003-1048-7978
이유미(Rhee, Yumie) ORCID logo https://orcid.org/0000-0003-4227-5638
이은직(Lee, Eun Jig) ORCID logo https://orcid.org/0000-0002-9876-8370
임승길(Lim, Sung Kil)
최한석(Choi, Han Seok)
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