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Clinical outcomes, when matched at presentation, do not vary between adult-onset Henöch-Schönlein purpura nephritis and IgA nephropathy.

Authors
 Hyung Jung Oh  ;  Song Vogue Ahn  ;  Dong Eun Yoo  ;  Seung Jun Kim  ;  Dong Ho Shin  ;  Mi Jung Lee  ;  Hyoung Rae Kim  ;  Jung Tak Park  ;  Tae-Hyun Yoo  ;  Shin-Wook Kang  ;  Kyu Hun Choi  ;  Seung Hyeok Han 
Citation
 KIDNEY INTERNATIONAL, Vol.82(12) : 1304-1312, 2012 
Journal Title
 KIDNEY INTERNATIONAL 
ISSN
 0085-2538 
Issue Date
2012
MeSH
Adolescent ; Adult ; Biomarkers/blood ; Biopsy ; Chi-Square Distribution ; Creatinine/blood ; Disease Progression ; Disease-Free Survival ; Female ; Glomerular Filtration Rate ; Glomerulonephritis, IGA/complications ; Glomerulonephritis, IGA/diagnosis* ; Glomerulonephritis, IGA/pathology ; Glomerulonephritis, IGA/physiopathology ; Glomerulonephritis, IGA/therapy ; Humans ; Kaplan-Meier Estimate ; Kidney/pathology ; Kidney/physiopathology ; Kidney Failure, Chronic/etiology ; Male ; Middle Aged ; Multivariate Analysis ; Nephritis/diagnosis* ; Nephritis/etiology ; Nephritis/pathology ; Nephritis/physiopathology ; Nephritis/therapy ; Propensity Score ; Proportional Hazards Models ; Purpura, Schoenlein-Henoch/complications* ; Republic of Korea ; Retrospective Studies ; Time Factors ; Young Adult
Keywords
clinical outcomes ; HSP nephritis ; IgA nephropathy
Abstract
Henöch-Schönlein purpura nephritis (HSPN) is considered a systemic form of immunoglobulin A nephropathy (IgAN). Although these are different pictures of a single disease, there are no studies directly comparing long-term outcomes of these two clinical entities. To clarify this, we studied 120 patients with biopsy-proven HSPN and 1070 patients with IgAN. The primary outcome was the composite of a doubling of baseline serum creatinine, end-stage renal disease, or death. Secondary outcomes included the individual renal outcomes or the rate of decline in estimated glomerular filtration rate. In the unmatched cohort, patients with HSPN had more vasculitic symptoms, more favorable histologic features, and were more commonly treated with steroids than patients with IgAN. The risk of reaching the primary outcome was significantly lower in HSPN patients than patients with IgAN (hazard ratio, 0.67). The 1:2 propensity score matching gave matched pairs of 89 patients with HSPN and 178 patients with IgAN, resulting in no differences in baseline conditions. In this matched cohort, there were no significant differences in reaching the primary and secondary outcomes between the two groups. Thus, after adjustment by propensity score matching, clinical outcomes did not differ between HSPN and IgAN, suggesting the two forms of the same disease have a similar prognosis.
Full Text
http://www.kidney-international.org/article/S0085-2538(15)56088-2/abstract
DOI
22895518
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Seung Jun(김승준)
Kim, Hyoung Rae(김형래)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Oh, Hyung Jung(오형중)
Yoo, Dong Eun(유동은)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Mi Jung(이미정)
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91199
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