Complete genome sequence of the podoviral bacteriophage YMC/09/02/B1251 ABA BP, which causes the lysis of an OXA-23-producing carbapenem-resistant Acinetobacter baumannii isolate from a septic patient

Jongsoo Jeon; Jae-won Kim; Dongeun Yong; Kyungwon Lee; Yunsop Chong

doi:10.1128/JVI.02132-12

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Complete genome sequence of the podoviral bacteriophage YMC/09/02/B1251 ABA BP, which causes the lysis of an OXA-23-producing carbapenem-resistant Acinetobacter baumannii isolate from a septic patient

Authors: Jongsoo Jeon ; Jae-won Kim ; Dongeun Yong ; Kyungwon Lee ; Yunsop Chong

Citation: JOURNAL OF VIROLOGY, Vol.86(22) : 12437-12438, 2012

Journal Title: JOURNAL OF VIROLOGY

ISSN: 0022-538X

Issue Date: 2012

MeSH: Acinetobacter baumannii/virology* ; Anti-Bacterial Agents/pharmacology ; Bacteriophages/genetics* ; Carbapenems/pharmacology ; DNA Viruses/genetics ; DNA, Circular/genetics ; Drug Resistance, Bacterial/genetics ; Genome, Viral ; Humans ; Molecular Sequence Data ; Podoviridae/genetics* ; Sepsis/complications ; Sepsis/virology ; Sequence Analysis, DNA ; Virus Diseases/complications ; Virus Diseases/virology

Keywords: Acinetobacter baumannii/virology* ; Anti-Bacterial Agents/pharmacology ; Bacteriophages/genetics* ; Carbapenems/pharmacology ; DNA Viruses/genetics ; DNA, Circular/genetics ; Drug Resistance, Bacterial/genetics ; Genome, Viral ; Humans ; Molecular Sequence Data ; Podoviridae/genetics* ; Sepsis/complications ; Sepsis/virology ; Sequence Analysis, DNA ; Virus Diseases/complications ; Virus Diseases/virology

Abstract: The emergence of carbapenem-resistant Acinetobacter baumannii, responsible for causing nosocomial infections, has been becoming a significant global health issue. In this article, we report the complete genome sequence of bacteriophage B-B1251 (YMC/09/02/B1251 ABA BP), which causes lysis of a carbapenem-resistant A. baumannii strain. The bacteriophage belongs to the family Podoviridae and has a double-stranded circular DNA genome with a length of 45,364 bp and a 39.05% G+C content. Genome analysis showed that it had no similarity to other previously reported bacteriophages capable of infecting A. baumannii.