Feasibility of measuring 3-dimensional renal parenchymal volume to predict postnatal renal function in near-term fetuses with congenital hydronephrosis: a preliminary study

Abstract

OBJECTIVES: The purposes of this study were to evaluate the feasibility of predicting kidney function using the fetal renal parenchymal volume as determined by prenatal 3-dimensional (3D) sonography and to determine the association among the prenatal renal pelvic diameter, renal parenchymal volume, and postnatal renal function in near-term fetuses with unilateral hydronephrosis.

METHODS: This retrospective study included 42 kidneys (21 normal and 21 hydronephrotic) from 21 fetuses between 30 and 39 weeks' gestation. We used the extended imaging virtual organ computer-aided analysis (XI VOCAL; 10 planes) technique for the prenatal volumetric measurements, and postnatal renal function was estimated using renal scintigraphy. An independent-samples Student ttest, Spearman's rank correlation, and simple linear regression were used for the statistical analyses. Reproducibility was confirmed with a paired Student t test and intraclass correlation coefficients.

RESULTS: The renal pelvic diameter correlated well with the renal parenchymal volume Spearman ρ = 0.765; P < .001). The postnatal renal function correlated with the adjusted 3D renal parenchymal volume (Spearman ρ = -0.321; P = .043) but did not correlate with the prenatal renal pelvic diameter (Spearman ρ = -0.291; P = .062).

CONCLUSIONS: This preliminary study showed that 3D renal parenchymal volume could be a coparameter for predicting postnatal renal function with the renal pelvic diameter. Further studies in a larger population are required to obtain robust results.