4 355

Cited 0 times in

The significance of detrusor wall thickness as a prognostic factor in pediatric bladder outlet obstruction

Authors
 Yong Seung Lee  ;  Hyun Jin Jung  ;  Young Jae Im  ;  Chang Hee Hong  ;  Sang Won Han 
Citation
 JOURNAL OF PEDIATRIC SURGERY, Vol.47(9) : 1682-1687, 2012 
Journal Title
JOURNAL OF PEDIATRIC SURGERY
ISSN
 0022-3468 
Issue Date
2012
MeSH
Biomarkers/blood ; Creatinine/blood ; Follow-Up Studies ; Humans ; Infant ; Logistic Models ; Multivariate Analysis ; Prognosis ; ROC Curve ; Recovery of Function ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Ultrasonography ; Urinary Bladder/diagnostic imaging* ; Urinary Bladder/pathology ; Urinary Bladder/physiopathology ; Urinary Bladder Neck Obstruction/blood ; Urinary Bladder Neck Obstruction/diagnostic imaging* ; Urinary Bladder Neck Obstruction/pathology ; Urinary Bladder Neck Obstruction/therapy
Keywords
Bladder outlet obstruction ; Ultrasonography ; Creatinine
Abstract
PURPOSE: The purpose of this study is to determine detrusor thickness as a prognostic factor in posterior urethral valves.

METHODS: The medical information of 41 patients diagnosed with posterior urethral valves at our institute was retrospectively reviewed. The serum creatinine level after bladder decompression, results of ultrasonography, and voiding cystourethrography were compared between groups divided according to the final bladder and renal function. Detrusor thickness was measured using Müller's method.

RESULTS: The median detrusor thickness was 1.3 mm (0.4-2.5 mm). After median 45.6 months (7.2-96.0 months) of follow-up, impaired bladder function (IBF) was observed in 14 patients. In multivariate analysis, detrusor thickness greater than 1.3 mm (odds ratio, 32.6; 95% confidence interval, 3.1-340.6; P = .004) was the only independent risk factor for later IBF. Final renal function impairment developed in 24 patients (58.5%), and 3 patients (7.3%) were diagnosed with end-stage renal disease after median 66.0 months (32.4-133.2 months) of follow-up period. On multivariate analysis, age-specific elevated serum creatinine level at presentation (odds ratio, 11.1; 95% confidence interval, 1.1-112.5; P = .042) was an independent risk factor.

CONCLUSIONS: Detrusor thickness more than 1.3 mm on ultrasonography was an independent prognostic factor for later IBF.
Full Text
http://www.sciencedirect.com/science/article/pii/S002234681200293X
DOI
22974606
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Seung(이용승) ORCID logo https://orcid.org/0000-0003-3778-9888
Im, Young Jae(임영재)
Jung, Hyun Jin(정현진)
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
Hong, Chang Hee(홍창희) ORCID logo https://orcid.org/0000-0002-0946-7702
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91037
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links