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The significance of detrusor wall thickness as a prognostic factor in pediatric bladder outlet obstruction

Authors
 Yong Seung Lee  ;  Hyun Jin Jung  ;  Young Jae Im  ;  Chang Hee Hong  ;  Sang Won Han 
Citation
 Journal of Pediatric Surgery, Vol.47(9) : 1682-1687, 2012 
Journal Title
 Journal of Pediatric Surgery 
ISSN
 0022-3468 
Issue Date
2012
Abstract
PURPOSE: The purpose of this study is to determine detrusor thickness as a prognostic factor in posterior urethral valves. METHODS: The medical information of 41 patients diagnosed with posterior urethral valves at our institute was retrospectively reviewed. The serum creatinine level after bladder decompression, results of ultrasonography, and voiding cystourethrography were compared between groups divided according to the final bladder and renal function. Detrusor thickness was measured using Müller's method. RESULTS: The median detrusor thickness was 1.3 mm (0.4-2.5 mm). After median 45.6 months (7.2-96.0 months) of follow-up, impaired bladder function (IBF) was observed in 14 patients. In multivariate analysis, detrusor thickness greater than 1.3 mm (odds ratio, 32.6; 95% confidence interval, 3.1-340.6; P = .004) was the only independent risk factor for later IBF. Final renal function impairment developed in 24 patients (58.5%), and 3 patients (7.3%) were diagnosed with end-stage renal disease after median 66.0 months (32.4-133.2 months) of follow-up period. On multivariate analysis, age-specific elevated serum creatinine level at presentation (odds ratio, 11.1; 95% confidence interval, 1.1-112.5; P = .042) was an independent risk factor. CONCLUSIONS: Detrusor thickness more than 1.3 mm on ultrasonography was an independent prognostic factor for later IBF.
Full Text
http://www.sciencedirect.com/science/article/pii/S002234681200293X
DOI
10.1016/j.jpedsurg.2012.03.051
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
이용승(Lee, Yong Seung) ORCID logo https://orcid.org/0000-0003-3778-9888
임영재(Im, Young Jae)
정현진(Jung, Hyun Jin)
한상원(Han, Sang Won) ORCID logo https://orcid.org/0000-0003-0941-1300
홍창희(Hong, Chang Hee) ORCID logo https://orcid.org/0000-0002-0946-7702
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91037
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