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Psychological and behavioral effects of chloral hydrate in day-case pediatric surgery: a randomized, observer-blinded study

 Hae K. Kil  ;  Won O. Kim  ;  Sang W. Han  ;  Youngjun Kwon  ;  Aerina Lee  ;  Jeong-Yeon Hong 
 JOURNAL OF PEDIATRIC SURGERY, Vol.47(8) : 1592-1599, 2012 
Journal Title
Issue Date
Ambulatory Surgical Procedures* ; Anesthetics, General/adverse effects ; Anti-Anxiety Agents/administration & dosage ; Anti-Anxiety Agents/adverse effects ; Anti-Anxiety Agents/pharmacology* ; Anti-Anxiety Agents/therapeutic use ; Anxiety/epidemiology ; Anxiety/prevention & control ; Child Behavior/drug effects* ; Child, Preschool ; Chloral Hydrate/administration & dosage ; Chloral Hydrate/adverse effects ; Chloral Hydrate/pharmacology* ; Chloral Hydrate/therapeutic use ; Delirium/chemically induced ; Delirium/epidemiology ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/adverse effects ; Hypnotics and Sedatives/pharmacology* ; Hypnotics and Sedatives/therapeutic use ; Infant ; Male ; Orchiopexy ; Pain, Postoperative/epidemiology ; Pain, Postoperative/prevention & control* ; Patient Compliance ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control* ; Prospective Studies ; Psychomotor Agitation/prevention & control ; Single-Blind Method
Anxiety ; Delirium ; Induction compliance ; Pediatric ; Postoperative pain ; Maladaptive behavior
BACKGROUND/PURPOSE: This prospective, randomized, and observer-blinded study was performed to evaluate the effects of oral chloral hydrate on perioperative psychological and behavioral phenomena in children. METHODS: In total, 100 boys (age, 1-5 years) scheduled for day-case unilateral orchiopexy were randomly allocated into 2 groups and orally administered either 40 mg/kg of chloral hydrate (CH group) or placebo (control group) 30 minutes before surgery, followed by assessment of anxiety, induction compliance, emergence delirium, postoperative pain, and maladaptive behavioral changes. RESULTS: Anxiety scores were significantly lower in the CH group compared with the control group (45.7 vs 28.8). The induction compliance of the CH group was better than that of the control group (3.2 vs 4.8). Postoperative sedation was more frequent (62.7% vs 20.4%); however, the incidence of vomiting was lower (2.0% vs 14.3%) in the CH group than in the control group. Postoperative emergence delirium and maladaptive behavior changes were similar between the 2 groups. CONCLUSION: Decreasing preoperative anxiety with oral chloral hydrate improves induction compliance and reduces postoperative pain intensity without delaying recovery in young boys. However, chloral hydrate had little impact on emergence delirium and postoperative maladaptive behavior.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kil, Hae Keum(길혜금)
Kim, Won Oak(김원옥)
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
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