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Neuroanatomical substrates of visual hallucinations in patients with non-demented Parkinson's disease

Authors
 Soojeong Shin  ;  Ji Eun Lee  ;  Jin Yong Hong  ;  Mun-Kyung Sunwoo  ;  Young Ho Sohn  ;  Phil Hyu Lee 
Citation
 Journal of Neurology, Neurosurgery and Psychiatry, Vol.83(12) : 1155-1161, 2012 
Journal Title
 Journal of Neurology, Neurosurgery and Psychiatry 
ISSN
 0022-3050 
Issue Date
2012
MeSH
Aged ; Brain/pathology ; Cognition ; Female ; Hallucinations/etiology ; Hallucinations/pathology* ; Hallucinations/psychology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Memory ; Neurologic Examination ; Neuropsychological Tests ; Parasympathetic Nervous System/pathology ; Parkinson Disease/complications ; Parkinson Disease/pathology* ; Parkinson Disease/psychology ; Socioeconomic Factors ; Substantia Innominata/pathology
Keywords
Aged ; Brain/pathology ; Cognition ; Female ; Hallucinations/etiology ; Hallucinations/pathology* ; Hallucinations/psychology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Memory ; Neurologic Examination ; Neuropsychological Tests ; Parasympathetic Nervous System/pathology ; Parkinson Disease/complications ; Parkinson Disease/pathology* ; Parkinson Disease/psychology ; Socioeconomic Factors ; Substantia Innominata/pathology
Abstract
BACKGROUND: Visual hallucinations (VH), which are common in patients with Parkinson's disease (PD), lead to increased disability and are a significant predictor of the development of dementia. However, the neuroanatomical basis for VH in non-demented PD patients remains controversial. METHODS: A total of 110 patients with PD were classified into PD with VH (n=46) and PD without VH (n=64) groups, depending on the presence of VH assessed by the caregiver-based structured interview of the Neuropsychiatric Inventory. We performed voxel-based morphometry (VBM) for grey matter (GM) volume and a region-of-interest-based volumetric analysis of the substantia innominata (SI) between two groups. RESULTS: The comprehensive neuropsychological assessment showed that PD patients with VH showed more severe cognitive deficits in delayed visual memory and frontal executive functions compared with those without VH. A VBM analysis revealed that PD patients with VH had significantly lower GM volume in the right orbitofrontal, left temporal and left thalamic areas compared with those without VH. The normalised SI volume was significantly reduced in PD patients with VH compared with those without VH (1.28 ± 0.22 vs 1.41 ± 0.25, p=0.005). CONCLUSIONS: The present study demonstrates that non-demented PD patients with VH exhibited a smaller volume in the frontal, temporal and thalamic areas as well as the SI, suggesting that PD hallucinators may have distinctive neuroanatomical bases relative to PD non-hallucinators.
Full Text
http://jnnp.bmj.com/content/83/12/1155.long
DOI
22933812
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sunwoo, Mun Kyung(선우문경)
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Hong, Jin Yong(홍진용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90991
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