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The pattern of cortical atrophy in Parkinson's disease with mild cognitive impairment according to the timing of cognitive dysfunction

Authors
 Ji E. Lee  ;  Kyoo H. Cho  ;  Myonghwan Kim  ;  Young H. Sohn  ;  Phil Hyu Lee 
Citation
 JOURNAL OF NEUROLOGY, Vol.259(3) : 469-473, 2012 
Journal Title
 JOURNAL OF NEUROLOGY 
ISSN
 0340-5354 
Issue Date
2012
MeSH
Aged ; Atrophy/pathology ; Cerebral Cortex/pathology* ; Cognitive Dysfunction/complications* ; Cognitive Dysfunction/pathology* ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Parkinsonian Disorders/complications* ; Parkinsonian Disorders/pathology* ; Statistics, Nonparametric
Keywords
Parkinson’s disease ; Mild cognitive impairment ; Cortical atrophy ; Timing of cognitive dysfunction
Abstract
The density of Lewy bodies or the concurrent β-amyloid pathology would act as modulators in the relative timing of dementia during the course of Parkinson's disease. Depending on the temporal relationship between the onset of parkinsonism and that of cognitive impairment, patients with Parkinson's disease with mild cognitive impairment were divided into two groups of earlier (<1 year) and later (≥1 year) cognitive decline, and cortical atrophy patterns and correlation of gray matter and timing of cognitive decline were analyzed using voxel-based morphometry. The morphometric analysis showed that patients with earlier cognitive decline demonstrated greater cortical atrophy in the inferior parietal and orbitofrontal areas than did those with later cognitive decline. Additionally, the anatomical bases of the timing of their cognitive decline differed in terms of correlation patterns. These data suggest that the pathological burden in Parkinson's disease with mild cognitive impairment may be more severe in patients with earlier cognitive decline than in those with later cognitive decline, and that the neural basis corresponding to the timing of cognitive decline may differ in these patients.
Full Text
http://link.springer.com/article/10.1007%2Fs00415-011-6203-x
DOI
21818688
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Cho, Kyoo Ho(조규호) ORCID logo https://orcid.org/0000-0003-2402-7198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90989
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