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Senescence of fetal endothelial progenitor cell in pregnancy with idiopathic fetal growth

Authors
 Han Sung Hwang  ;  Young Guen Kwon  ;  Ja Young Kwon  ;  Yong Won Park  ;  Yong Sun Maeng  ;  Young Han Kim 
Citation
 JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, Vol.25(9) : 1769-1773, 2012 
Journal Title
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
ISSN
 1476-7058 
Issue Date
2012
MeSH
Adult ; Case-Control Studies ; Cell Differentiation/physiology ; Cell Proliferation ; Cell Separation ; Cells, Cultured ; Cellular Senescence/physiology* ; Endothelial Cells/cytology ; Endothelial Cells/pathology* ; Endothelial Cells/physiology* ; Female ; Fetal Growth Retardation/diagnostic imaging ; Fetal Growth Retardation/pathology* ; Fetal Growth Retardation/physiopathology ; Fetal Stem Cells/cytology ; Fetal Stem Cells/pathology ; Fetal Stem Cells/physiology* ; Humans ; Infant, Newborn ; Pregnancy ; Ultrasonography
Keywords
Endothelial progenitor cell ; fetal growth restriction ; senescence
Abstract
OBJECTIVE: The aim of our study was to investigate the change of count and the status of cellular senescence in fetal endothelial progenitor cells (EPCs) obtained from the umbilical cord blood of women with fetal growth restriction (FGR).

METHODS: Fetal EPCs were obtained from thirty five normal and thirty pregnant women with FGR. Each EPC was characterized and counted. EPC differentiation time and outgrowth endothelial cell (OEC) colony formation assay, senescence-associated β-galactosidase (SA-β-gal) activity assay, and telomerase activity assay were performed.

RESULTS: Fetal EPC counts were significantly decreased in the FGR group compared with normal controls. In the FGR group, the EPC differentiation time was prolonged, OEC colonies were much less formed, the staining intensity of SA-β-gal was relatively increased and the telomerase activity of EPCs was significantly decreased, compared with normal pregnancy (p < 0.001 for all).

CONCLUSIONS: The fetal EPCs in FGR pregnancies were decreased, functionally impaired and senescently altered.
Full Text
http://informahealthcare.com/doi/abs/10.3109/14767058.2012.663826
DOI
22339619
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90957
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