198 385

Cited 0 times in

Spot urine albumin to creatinine ratio and serum cystatin C are effective for detection of diabetic nephropathy in childhood diabetic patients

Authors
 Hyun-Wook Chae  ;  Jae-Il Shin  ;  Ah-Reum Kwon  ;  Ho-Seong Kim  ;  Duk-Hee Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.27(7) : 784-787, 2012 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2012
MeSH
Adolescent ; Albuminuria/urine* ; Child ; Creatinine/urine* ; Cystatin C/blood* ; Diabetes Mellitus, Type 1/diagnosis* ; Diabetes Mellitus, Type 2/diagnosis* ; Diabetic Nephropathies/diagnosis* ; Female ; Glomerular Filtration Rate ; Glycated Hemoglobin A/analysis ; Humans ; Kidney Function Tests ; Male ; Predictive Value of Tests ; ROC Curve
Keywords
Albumin to Creatinine Ratio ; Childhood Diabetes ; Cystatin C ; Diabetic Nephropathies
Abstract
Spot urinary albumin to creatinine ratio (ACR) measurement has been suggested as a surrogate to 24-hr urine collection for the assessment of microalbuminuria, and cystatin C (cysC) is known as an advantageous marker for renal function. The aim of this study was to evaluate the clinical values of spot urinary ACR and serum cysC for the assessment of diabetic nephropathy instead of 24-hr urine microalbumin in children and adolescents with diabetes. A total of 113 children and adolescents (age 12-19 yr, M:F = 47:66) with type 1 or 2 diabetes were enrolled. We evaluated the validity of spot urine ACR and serum cysC, and then compared them to 24-hr urine microalbumin and creatinine clearance. Spot urine ACR was correlated with 24-hr urine albumin excretion (R(2) = 0.828, P = 0.001) and creatinine clearance (R(2) = 0.249, P = 0.017). The ROC curve analysis of serum cysC demonstrated higher diagnostic accuracy than that of serum creatinine (AUC 0.732 vs 0.615). Both the measurements of spot urine ACR and serum cysC might better predict the presence of diabetic nephropathy than 24-hr urine microalbumin in childhood diabetic patients.
Files in This Item:
T201203924.pdf Download
DOI
22787375
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ah Reum(권아름) ORCID logo https://orcid.org/0000-0002-9692-2135
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Chae, Hyun Wook(채현욱) ORCID logo https://orcid.org/0000-0001-5016-8539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90913
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse