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Innovative in vitro chemo-hormonal drug therapy for refractory thyroid carcinomas

Authors
 Tae-Yon Sung  ;  Sung Ho Choi  ;  Jung Min Lee  ;  Jong Ju Jeong  ;  Sang-Wook Kang  ;  Woong Youn Chung 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.27(7) : 729-735, 2012 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2012
MeSH
Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/pharmacology ; Adenosine Triphosphate/therapeutic use ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology* ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Cell Line, Tumor ; Etoposide/chemistry ; Etoposide/pharmacology ; Etoposide/therapeutic use ; Humans ; Hydroxamic Acids/chemistry ; Hydroxamic Acids/pharmacology ; Hydroxamic Acids/therapeutic use ; Thyroid Neoplasms/drug therapy ; Vincristine/chemistry ; Vincristine/pharmacology ; Vincristine/therapeutic use
Keywords
ATP-CRA ; Chemotherapy Drugs ; Hormonal Therapy Drugs ; Refractory Thyroid Carcinoma ; Thyroid Carcinoma Cell Lines
Abstract
More than 95% of the thyroid carcinomas are well differentiated types showing favorable prognosis. However, only a few therapeutic options are available to treat the patients with undifferentiated thyroid carcinomas, especially with refractory thyroid carcinomas that are not amenable to surgery or radioiodine ablation. We investigated the anticancer effects of 20 chemotherapy and hormonal therapy drugs on 8 thyroid carcinoma cell lines. In vitro chemosensitivity was tested using the adenosine-triphosphate-based chemotherapy response assay (ATP-CRA). The tumor inhibition rate (TIR; or cell death rate) or half maximal inhibitory concentration (IC(50)) was analyzed to interpret the results. Of the 12 chemotherapy drugs, etoposide (178.9 index value in follicular carcinoma cell line) and vincristine (211.7 in Hürthle cell carcinoma cell line) were the most active drugs showing the highest chemosensitivity, and of the 8 additional drugs, trichostatin A (0.03 µg/mL IC(50) in follicular carcinoma cell line) showed favorable outcome having the anticancer effect. In our study, the result of etoposide and vincristine show evidence as active anticancer drugs in thyroid carcinoma cell lines and trichostatin A seems be the next promising drug. These drugs may become an innovative therapy for refractory thyroid carcinomas in near future.
Files in This Item:
T201203410.pdf Download
DOI
22787366
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Wook(강상욱) ORCID logo https://orcid.org/0000-0001-5355-833X
Chung, Woong Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90909
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