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Coexistence of chronic lymphocytic thyroiditis with papillary thyroid carcinoma: clinical manifestation and prognostic outcome

 Jun Soo Jeong  ;  Hyun Ki Kim  ;  Cho-Rok Lee  ;  Seulkee Park  ;  Jae Hyun Park  ;  Sang-Wook Kang  ;  Jong Ju Jeong  ;  Kee-Hyun Nam  ;  Woong Youn Chung  ;  Cheong Soo Park 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.27(8) : 883-889, 2012 
Journal Title
Issue Date
Adult ; Carcinoma/complications ; Carcinoma/diagnosis* ; Carcinoma/surgery ; Carcinoma, Papillary/complications ; Carcinoma, Papillary/diagnosis* ; Carcinoma, Papillary/surgery ; Disease-Free Survival ; Female ; Follow-Up Studies ; Hashimoto Disease/complications ; Hashimoto Disease/mortality ; Hashimoto Disease/pathology* ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Odds Ratio ; Predictive Value of Tests ; Prognosis ; Recurrence ; Sex Factors ; Survival Rate ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/diagnosis* ; Thyroid Neoplasms/surgery ; Thyroidectomy
Chronic Lymphocytic Thyroiditis ; Papillary Thyroid Carcinoma ; Prognostic Outcome ; Recurrence
The study aimed to identify the clinical characteristics of coexisting chronic lymphocytic thyroiditis (CLT) in papillary thyroid carcinoma (PTC) and to evaluate the influence on prognosis. A total of 1,357 patients who underwent thyroid surgery for PTC were included. The clinicopathological characteristics were identified. Patients who underwent total thyroidectomy (n = 597) were studied to evaluate the influence of coexistent CLT on prognosis. Among the total 1,357 patients, 359 (26.5%) had coexistent CLT. In the CLT group, the prevalence of females was higher than in the control group without CLT (P < 0.001). Mean tumor size and mean age in the patients with CLT were smaller than without CLT (P = 0.040, P = 0.047, respectively). Extrathyroidal extension in the patients with CLT was significantly lower than without CLT (P = 0.016). Among the subset of 597 patients, disease-free survival rate in the patients with CLT was significantly higher than without CLT (P = 0.042). However, the multivariate analysis did not reveal a negative association between CLT coexistence and recurrence. Patients with CLT display a greater female preponderance, smaller size, younger and lower extrathyroidal extension. CLT is not a significant independent negative predictive factor for recurrence, although presence of CLT indicates a reduced risk of recurrence.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Wook(강상욱) ORCID logo https://orcid.org/0000-0001-5355-833X
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Park, Seul Kee(박슬기)
Park, Jae Hyun(박재현)
Park, Cheong Soo(박정수)
Lee, Cho Rok(이초록) ORCID logo https://orcid.org/0000-0001-7848-3709
Chung, Woung Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
Jeong, Jun Soo(정준수)
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