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Mycobacterial pulmonary infections in patients with idiopathic pulmonary fibrosis

Authors
 Sung-Woo Park ; Jin Woo Song ; Tae Sun Shim ; Moo-Suk Park ; Hong-Lyeol Lee ; Soo-Taek Uh ; Choon-Sik Park ; Dong Soon Kim 
Citation
 Journal of Korean Medical Science, Vol.27(8) : 896~900, 2012 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2012
Abstract
Patients with idiopathic pulmonary fibrosis (IPF) have an increased risk for developing tuberculosis (TB). However, no studies have been reported regarding the development of nontuberculous mycobacterium (NTM) lung disease (NTMLD). We reviewed 795 patients with IPF from five university hospitals who were diagnosed by histological or radio-clinical criteria. In the 795 patients with IPF, pulmonary infections with mycobacterium tuberculosis (MTB) and NTM were found in 35 (4.4%) and 16 patients (2.0%), respectively, which was a higher frequency than that found in the general population. TB was more common in patients treated with immunosuppressants than in those who did not receive immunosuppressants (2.6% vs 1.4%, P = 0.12). Among the IPF patients who had mycobacterial infections,immunosuppressant users developed TB or NTMLD within 1 yr after treatment with immunosuppressants,while those occurred later than 2 yr after diagnosis of IPF in the subjects that did not receive immunosuppressants. Among 51 IPF patients who had mycobacterial infections, 9 (18%) died during follow-up. Of these, three died due to progression of pulmonary tuberculosis. TB and NTMLD is relatively common in patients with IPF in Korea and may be fatal in some groups. Careful evaluation of TB and NTMLD is necessary not only for immunosuppressant users, but also for nonusers with IPF.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90900
DOI
10.3346/jkms.2012.27.8.896
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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