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Identification of HnRNP-A2/B1 as a target antigen of anti-endothelial cell IgA antibody in Behçet's disease.

DC Field Value Language
dc.contributor.author조성빈-
dc.contributor.author강신욱-
dc.contributor.author김도희-
dc.contributor.author박용범-
dc.contributor.author방동식-
dc.contributor.author이광훈-
dc.contributor.author이주희-
dc.contributor.author정진룡-
dc.date.accessioned2014-12-19T17:09:02Z-
dc.date.available2014-12-19T17:09:02Z-
dc.date.issued2012-
dc.identifier.issn0022-202X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90869-
dc.description.abstractBehçet's disease (BD) is a chronic, multisystemic vasculitis that theoretically affects all sizes and types of blood vessels. Although pathogenesis remains enigmatic, endothelial cells are believed to be the primary target in this disease. We detected the target protein using western blotting and immunoprecipitation and determined the amino-acid sequence of the peptide by liquid chromatography-matrix assisted laser desorption/ionization-tandem time-of-flight analysis (LC-MALDI-TOF/TOF). Serum reactivity against the recombinant target protein was analyzed by immunoblotting. Serum reactivity against streptococcal 65-kD heat shock protein (hsp-65) and the recombinant target protein was investigated by ELISA. The 36-40-kD protein band that was obtained from immunoprecipitation, which was analyzed by LC-MALDI-TOF/TOF, exhibited the amino-acid sequences of heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP-A2/B1). Reactivity of serum IgA against human recombinant hnRNP-A2/B1 was detected in 25 of 30 BD patients (83.3%), 4 of 30 systemic lupus erythematosus patients (13.3%), 8 of 30 rheumatoid arthritis patients (26.7%), 9 of 30 Takayasu's arteritis patients (30%), 6 of 30 healthy controls (20%), and none of 30 IgA nephropathy patients. Optical densities obtained from ELISAs against the recombinant human hnRNP-A2/B1 were correlated with those against the recombinant streptococcal hsp-65.JID JOURNAL CLUB ARTICLE: For questions, answers, and open discussion about this article, please go to http://www.nature.com/jid/journalclub.-
dc.description.statementOfResponsibilityopen-
dc.format.extent601~608-
dc.relation.isPartOfJOURNAL OF INVESTIGATIVE DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHArthritis, Rheumatoid/blood-
dc.subject.MESHArthritis, Rheumatoid/immunology-
dc.subject.MESHAutoantibodies/blood-
dc.subject.MESHAutoantibodies/immunology*-
dc.subject.MESHAutoantigens/immunology*-
dc.subject.MESHBacterial Proteins/immunology-
dc.subject.MESHBehcet Syndrome/blood-
dc.subject.MESHBehcet Syndrome/immunology*-
dc.subject.MESHFemale-
dc.subject.MESHGlomerulonephritis, IGA/blood-
dc.subject.MESHGlomerulonephritis, IGA/immunology-
dc.subject.MESHHeterogeneous-Nuclear Ribonucleoprotein Group A-B/immunology*-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin A/blood-
dc.subject.MESHImmunoglobulin A/immunology*-
dc.subject.MESHLupus Erythematosus, Systemic/blood-
dc.subject.MESHLupus Erythematosus, Systemic/immunology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHStreptococcus/immunology-
dc.subject.MESHTakayasu Arteritis/blood-
dc.subject.MESHTakayasu Arteritis/immunology-
dc.titleIdentification of HnRNP-A2/B1 as a target antigen of anti-endothelial cell IgA antibody in Behçet's disease.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSung Bin Cho-
dc.contributor.googleauthorKeun Jae Ahn-
dc.contributor.googleauthorDo Hee Kim-
dc.contributor.googleauthorZhenlong Zheng-
dc.contributor.googleauthorSuhyun Cho-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorJu Hee Lee-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorKwang Hoon Lee-
dc.contributor.googleauthorDongsik Bang-
dc.identifier.doi22205302-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03832-
dc.contributor.localIdA00053-
dc.contributor.localIdA01579-
dc.contributor.localIdA01784-
dc.contributor.localIdA03741-
dc.contributor.localIdA03171-
dc.contributor.localIdA02674-
dc.contributor.localIdA00395-
dc.relation.journalcodeJ01469-
dc.identifier.eissn1523-1747-
dc.identifier.pmid22205302-
dc.identifier.urlhttp://www.nature.com/jid/journal/v132/n3-1/full/jid2011397a.html-
dc.subject.keywordAdult-
dc.subject.keywordAmino Acid Sequence-
dc.subject.keywordArthritis, Rheumatoid/blood-
dc.subject.keywordArthritis, Rheumatoid/immunology-
dc.subject.keywordAutoantibodies/blood-
dc.subject.keywordAutoantibodies/immunology*-
dc.subject.keywordAutoantigens/immunology*-
dc.subject.keywordBacterial Proteins/immunology-
dc.subject.keywordBehcet Syndrome/blood-
dc.subject.keywordBehcet Syndrome/immunology*-
dc.subject.keywordFemale-
dc.subject.keywordGlomerulonephritis, IGA/blood-
dc.subject.keywordGlomerulonephritis, IGA/immunology-
dc.subject.keywordHeterogeneous-Nuclear Ribonucleoprotein Group A-B/immunology*-
dc.subject.keywordHumans-
dc.subject.keywordImmunoglobulin A/blood-
dc.subject.keywordImmunoglobulin A/immunology*-
dc.subject.keywordLupus Erythematosus, Systemic/blood-
dc.subject.keywordLupus Erythematosus, Systemic/immunology-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordMolecular Sequence Data-
dc.subject.keywordStreptococcus/immunology-
dc.subject.keywordTakayasu Arteritis/blood-
dc.subject.keywordTakayasu Arteritis/immunology-
dc.contributor.alternativeNameCho, Sung Bin-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKim, Do Hee-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameBang, Dong Sik-
dc.contributor.alternativeNameLee, Kwang Hoon-
dc.contributor.alternativeNameLee, Ju Hee-
dc.contributor.alternativeNameZheng, Zhen Long-
dc.contributor.affiliatedAuthorCho, Sung Bin-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorBang, Dong Sik-
dc.contributor.affiliatedAuthorZheng, Zhen Long-
dc.contributor.affiliatedAuthorLee, Ju Hee-
dc.contributor.affiliatedAuthorLee, Kwang Hoon-
dc.contributor.affiliatedAuthorKim, Do Hee-
dc.citation.volume132-
dc.citation.number3 pt 1-
dc.citation.startPage601-
dc.citation.endPage608-
dc.identifier.bibliographicCitationJOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol.132(3 pt 1) : 601-608, 2012-
dc.identifier.rimsid34575-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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