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Comparison of three-year clinical outcomes with nonextended versus extended dual antiplatelet therapy between first- and second-generation drug-eluting stent implantation in patients with acute myocardial infarction: data from the infarct prognosis study registry

DC FieldValueLanguage
dc.contributor.author홍명기-
dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김중선-
dc.contributor.author장양수-
dc.contributor.author장지용-
dc.contributor.author최동훈-
dc.contributor.author하종원-
dc.contributor.author이혜선-
dc.date.accessioned2014-12-19T17:08:50Z-
dc.date.available2014-12-19T17:08:50Z-
dc.date.issued2012-
dc.identifier.issn0896-4327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90863-
dc.description.abstractBACKGROUND: The difference of the clinical outcomes between nonextended (≤12 months) and extended (>12 months) dual antiplatelet therapy (DAPT) remains unclear in patients with acute myocardial infarction (AMI) implanted by different generations of drug-eluting stent (DES). METHODS: We identified 790 consecutive patients with AMI who were free from major adverse cardiac events for 12 months after first-generation (n = 537) or second-generation DES (n = 253) implantation; each DES generation group was further divided into nonextended and extended DAPT. RESULTS: During follow-up (median: 40 months), nonextended DAPT in the first-generation DES group showed a higher rate of cardiac death or MI than was observed in the extended DAPT group (14% vs 2%, P < 0.001). However, in the second-generation DES group, there was no difference in the occurrence of cardiac death and MI between the extended and nonextended groups (4% vs 3%, P = 0.809). Nonextended DAPT was the most significant predictor of cardiac death and MI for first-generation DES implantation [hazard ratio (HR) = 5.47, 95% confidence interval (CI) = 1.53-19.59, P = 0.009] but not for second-generation DES implantation [HR = 3.21, 95% CI = 0.21-50.65, P = 0.401]. CONCLUSION: This study suggested that the clinical outcomes between nonextended and extended DAPT might be different depending on the generation of implanted DESs in patients with AMI.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF INTERVENTIONAL CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAngioplasty, Balloon, Coronary-
dc.subject.MESHCoronary Artery Disease/drug therapy*-
dc.subject.MESHCoronary Artery Disease/therapy-
dc.subject.MESHCoronary Thrombosis/prevention & control-
dc.subject.MESHDrug Administration Schedule-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHDrug-Eluting Stents*/adverse effects-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyocardial Infarction/drug therapy-
dc.subject.MESHMyocardial Infarction/therapy*-
dc.subject.MESHPlatelet Aggregation Inhibitors/administration & dosage*-
dc.subject.MESHPlatelet Aggregation Inhibitors/adverse effects-
dc.subject.MESHPrognosis-
dc.subject.MESHTreatment Outcome-
dc.titleComparison of three-year clinical outcomes with nonextended versus extended dual antiplatelet therapy between first- and second-generation drug-eluting stent implantation in patients with acute myocardial infarction: data from the infarct prognosis study registry-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학)-
dc.contributor.googleauthorKI-WOON KANG-
dc.contributor.googleauthorBYEONG-KEUK KIM-
dc.contributor.googleauthorJI-YONG JANG-
dc.contributor.googleauthorHYE SUN LEE-
dc.contributor.googleauthorJUNG-SUN KIM-
dc.contributor.googleauthorYOUNG-GUK KO-
dc.contributor.googleauthorJONGWON HA-
dc.contributor.googleauthorDONGHOON CHOI-
dc.contributor.googleauthorMYEONG-KI HONG-
dc.contributor.googleauthorYANGSOO JANG-
dc.identifier.doi22409626-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04391-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA03448-
dc.contributor.localIdA04053-
dc.contributor.localIdA04257-
dc.contributor.localIdA03476-
dc.contributor.localIdA03311-
dc.relation.journalcodeJ01465-
dc.identifier.eissn1540-8183-
dc.identifier.pmid22409626-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1540-8183.2012.00719.x/abstract-
dc.subject.keywordAged-
dc.subject.keywordAngioplasty, Balloon, Coronary-
dc.subject.keywordCoronary Artery Disease/drug therapy*-
dc.subject.keywordCoronary Artery Disease/therapy-
dc.subject.keywordCoronary Thrombosis/prevention & control-
dc.subject.keywordDrug Administration Schedule-
dc.subject.keywordDrug Therapy, Combination-
dc.subject.keywordDrug-Eluting Stents*/adverse effects-
dc.subject.keywordFemale-
dc.subject.keywordFollow-Up Studies-
dc.subject.keywordHumans-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordMyocardial Infarction/drug therapy-
dc.subject.keywordMyocardial Infarction/therapy*-
dc.subject.keywordPlatelet Aggregation Inhibitors/administration & dosage*-
dc.subject.keywordPlatelet Aggregation Inhibitors/adverse effects-
dc.subject.keywordPrognosis-
dc.subject.keywordTreatment Outcome-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameJang, Ji Yong-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHa, Jong Won-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHa, Jong Won-
dc.contributor.affiliatedAuthorJang Ji Yong-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.citation.volume25-
dc.citation.number3-
dc.citation.startPage245-
dc.citation.endPage252-
dc.identifier.bibliographicCitationJOURNAL OF INTERVENTIONAL CARDIOLOGY, Vol.25(3) : 245-252, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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