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A comparative analysis of hepatocellular carcinoma after hepatic resection in young versus elderly patients

Authors
 Cho Rok Lee  ;  Jin Hong Lim  ;  Sung Hoon Kim  ;  Sang Hoon Ahn  ;  Young Nyun Park  ;  Gi Hong Choi  ;  Jin Sub Choi  ;  Kyung Sik Kim 
Citation
 Journal of Gastrointestinal Surgery, Vol.16(9) : 1736-1743, 2012 
Journal Title
 Journal of Gastrointestinal Surgery 
ISSN
 1091-255X 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery* ; Child ; Female ; Hepatectomy ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery* ; Male ; Prognosis ; Retrospective Studies ; Survival Analysis ; Treatment Outcome ; Young Adult
Keywords
Hepatocellular carcinoma ; Age ; Hepatic resection
Abstract
PURPOSE: The aim of this study was to investigate the clinical outcomes after surgical treatment of hepatocellular carcinoma (HCC) in the elderly patients compared with younger patients. METHODS: Clinicopathological data and treatment outcomes in 61 elderly (≥70 years old) and 90 younger (≤40 years old) patients with HCC who underwent curative liver resection between 2000 and 2010 were retrospectively collected and compared using various parameters. RESULTS: The older HCC group was more likely to have hepatitis C virus and non-B non-C hepatitis virus infection, higher values of indocyanine green retention at 15 min (ICGR)(15), more preoperative comorbidities, and more postoperative complications. There were no significant differences in intraoperative parameters and pathologic features. The recurrence rate, overall survival and disease-free survival rates were similar amongst the two groups. The only independent prognostic factor of overall survival was postoperative complications. CONCLUSION: Our findings suggest that age by itself does not have an adverse effect on operative outcomes, including long-term prognosis. For young and elderly HCC patients, hepatic resection is a safe and effective treatment.
Full Text
http://link.springer.com/article/10.1007%2Fs11605-012-1966-7
DOI
22810298
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Cho Rok(이초록) ORCID logo https://orcid.org/0000-0001-7848-3709
Lim, Jin Hong(임진홍)
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
Choi, Jin Sub(최진섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90835
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