Cited 50 times in
The accuracy of noninvasive methods in predicting the development of hepatocellular carcinoma and hepatic decompensation in patients with chronic hepatitis B
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김도영 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 전영은 | - |
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 정규식 | - |
dc.contributor.author | 정은석 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2014-12-19T17:03:06Z | - |
dc.date.available | 2014-12-19T17:03:06Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0192-0790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90685 | - |
dc.description.abstract | BACKGROUND: Liver stiffness measurement (LSM) using transient elastography (FibroScan) can accurately assess the degree of liver fibrosis and predict the development of hepatocellular carcinoma (HCC) and variceal bleeding in patients with chronic hepatitis B (CHB). AIMS: We compared the accuracy of noninvasive liver fibrosis prediction methods in predicting the development of HCC or hepatic decompensation in patients with CHB. METHODS: A total of 1126 patients with CHB who underwent LSMs and attended regular follow-ups to detect the development of HCC and hepatic decompensations (variceal bleeding, ascites, hepatic encephalopathy, spontaneous bacterial peritonitis, or hepatorenal syndrome) were enrolled. Noninvasive liver fibrosis prediction methods included, age-spleen-to-platelet ratio index, LSM, LSM-spleen diameter-to-platelet ratio index (LSPI), P2/MS, and FIB-4. RESULTS: During follow-up (median, 30.7 mo), HCC and hepatic decompensation developed in 63 and 68 patients, respectively. The accuracy of LSM and LSPI in predicting the development of HCC or hepatic decompensation was higher than that of aspartate aminotransferase-to-platelet ratio index, age-spleen-to-platelet ratio index, P2/MS, or FIB-4 (areas under the receiver operating characteristic curve=0.789 and 0.788 vs. 0.729, 0.756, 0.696, and 0.744 for HCC development; areas under the receiver operating characteristic curve=0.820 and 0.848 vs. 0.787, 0.799, 0.812, and 0.784 for hepatic decompensation). On multivariate analyses, LSM and LSPI were identified as independent predictors of the development of HCC [hazard ratio (HR), 1.040 (LSM); HR, 1.001 (LSPI)] and hepatic decompensation [HR, 1.033 (LSM); HR, 1.002 (LSPI)]. CONCLUSIONS: Our results suggest that LSM or LSPI may be useful predictors of the development of HCC and hepatic decompensation in patients with CHB. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Carcinoma, Hepatocellular/diagnosis | - |
dc.subject.MESH | Carcinoma, Hepatocellular/etiology* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Elasticity Imaging Techniques | - |
dc.subject.MESH | Esophageal and Gastric Varices/etiology | - |
dc.subject.MESH | Esophageal and Gastric Varices/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Hepatitis B, Chronic/complications* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Cirrhosis/complications* | - |
dc.subject.MESH | Liver Cirrhosis/diagnosis | - |
dc.subject.MESH | Liver Cirrhosis/pathology | - |
dc.subject.MESH | Liver Neoplasms/diagnosis | - |
dc.subject.MESH | Liver Neoplasms/etiology* | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Organ Size | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Risk | - |
dc.subject.MESH | Spleen | - |
dc.title | The accuracy of noninvasive methods in predicting the development of hepatocellular carcinoma and hepatic decompensation in patients with chronic hepatitis B | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Chon, Young Eun | - |
dc.contributor.googleauthor | Jung, Eun Suk | - |
dc.contributor.googleauthor | Park, Jun Yong | - |
dc.contributor.googleauthor | Kim, Do Young | - |
dc.contributor.googleauthor | Ahn, Sang Hoon | - |
dc.contributor.googleauthor | Han, Kwang-Hyub | - |
dc.contributor.googleauthor | Chon, Chae Yoon | - |
dc.contributor.googleauthor | Jung, Kyu Sik | - |
dc.contributor.googleauthor | Kim, Seung Up | - |
dc.identifier.doi | 10.1097/MCG.0b013e31825079f1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A03532 | - |
dc.contributor.localId | A03578 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A03544 | - |
dc.contributor.localId | A03686 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J01319 | - |
dc.identifier.eissn | 1539-2031 | - |
dc.identifier.pmid | 22688146 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004836-201207000-00016&LSLINK=80&D=ovft | - |
dc.subject.keyword | chronic hepatitis B | - |
dc.subject.keyword | decompensation | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | prediction | - |
dc.subject.keyword | fibroscan | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Chon, Young Eun | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Jung, Kyu Sik | - |
dc.contributor.alternativeName | Jung, Eun Suk | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Chon, Young Eun | - |
dc.contributor.affiliatedAuthor | Jung, Kyu Sik | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Chon, Chae Yoon | - |
dc.contributor.affiliatedAuthor | Jung, Eun Suk | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 46 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 518 | - |
dc.citation.endPage | 525 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.46(6) : 518-525, 2012 | - |
dc.identifier.rimsid | 33466 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.