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The identification of significant chromosomal regions correlated with oral tongue cancer progression

 Ki-Yeol Kim  ;  In-Ho Cha 
 Journal of Cancer Research and Clinical Oncology, Vol.138(10) : 1667-1677, 2012 
Journal Title
 Journal of Cancer Research and Clinical Oncology 
Issue Date
Adult ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Chromosomes, Human, Pair 3* ; Disease Progression ; Early Diagnosis ; Female ; Gene Expression ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/genetics* ; Mouth Neoplasms/pathology* ; Prognosis ; Tongue Neoplasms/genetics* ; Tongue Neoplasms/pathology* ; Young Adult
Oral tongue squamous cell carcinoma ; Cancer progression ; Biomarker ; Array comparative genomic hybridization ; cDNA micoroarray data ; Prognostic factor
PURPOSE: Oral squamous cell carcinoma (OSCC) is associated with substantial mortality and morbidity, and oral tongue squamous cell carcinoma (SCC) is representative in OSCC. Early detection of oral premalignant lesions (OPLs) that will develop into invasive tumors is necessary to improve the poor prognosis of this cancer. METHODS: To identify potential biomarkers that could be used for early detection, we compared the gene expression of incident primary oral tongue SCC, severe dysplasia, mild and moderate dysplasia. For this, we used three expression datasets obtained from a public database and selected chromosomal locations related with the progress of oral tongue cancer from a dataset. We then evaluated the gene set, which is included in the selected chromosomal locations, using out of bag (OOB) error and plots in two validation datasets. RESULTS: Sixty-two chromosomal locations were detected, and most genomic aberrations were shown in chromosome 3. We identified 62 genes included in those locations, and three precancerous and SCC groups were well classified with low OOB error rates. These were also discriminative in the two validation datasets. CONCLUSIONS: The selected probes with genomic alteration in low-grade dysplasia can be used as an effective predictor for disease progression.
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
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