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Risk stratification of oral cancer patients using a combined prognostic factor including lymph node density and biomarker

 Ki-Yeol Kim  ;  In-Ho Cha 
 Journal of Cancer Research and Clinical Oncology, Vol.138(3) : 483-490, 2012 
Journal Title
 Journal of Cancer Research and Clinical Oncology 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Biomarkers, Tumor/analysis* ; Carcinoma, Squamous Cell/chemistry* ; Carcinoma, Squamous Cell/pathology* ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Lymph Nodes/pathology* ; Lymphatic Metastasis ; Male ; Middle Aged ; Mouth Neoplasms/chemistry* ; Mouth Neoplasms/pathology* ; Multivariate Analysis ; Neoplasm Staging ; Odds Ratio ; Predictive Value of Tests ; Prognosis ; RNA-Binding Proteins/analysis* ; Risk Assessment ; Risk Factors ; Up-Regulation
Oral squamous cell carcinoma ; Risk stratification ; Lymph node density ; Biomarker ; IMP3 ; Combined prognostic factor
PURPOSE: In this study, we aimed to validate the lymph node density (LND) as an independent prognostic factor of oral squamous cell carcinoma (OSCC) and identify a combined prognostic factor including LND, predicting better performance in risk stratification. METHODS: We reviewed the clinical, pathological variables and biomarker of 95 OSCC patients who underwent surgery. LND was calculated as the ratio of positive lymph nodes to total lymph nodes removed. Principle component analysis was performed to identify a combined predictor. RESULTS: Multivariate analysis showed that variables independently prognostic overall survival were IMP3 (hazard ratio [HR] = 3.01, 95% confidence interval [95% CI] = 1.17-7.75, P = 0.022) in a model without LND and were IMP3 (HR = 3.64, 95% CI = 1.38-9.58, P = 0.008) and LND (HR = 0.57, 95% CI = 0.57-1.75, P = 0.322; HR = 2.45, 95% CI = 1.20-4.97, P = 0.013) in a model with LND. The risk stratification using the combined prognostic factor was more significant (P = 0.00117) than the conventional staging system and biomarker. CONCLUSIONS: The LND was shown to be an independent prognostic factor in OSCC, and a combined factor including LND may be used for risk stratification of OSCC patients, which displayed the best performance.
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Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
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