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Association between γ-glutamyltransferase, adiponectin and arterial stiffness

Authors
 Jong Suk Park  ;  Sin Ae Kang  ;  Jeong Seon Yoo  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Kyung Rae Kim  ;  Hyun Chul Lee 
Citation
 JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, Vol.19(1) : 90-97, 2012 
Journal Title
 JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 
ISSN
 1340-3478 
Issue Date
2012
MeSH
Adiponectin/blood* ; Blood Flow Velocity ; Blood Pressure ; Body Mass Index ; Cross-Sectional Studies ; Female ; Humans ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/epidemiology ; Middle Aged ; Prognosis ; Pulsatile Flow ; Republic of Korea/epidemiology ; Risk Factors ; Vascular Stiffness* ; gamma-Glutamyltransferase/blood*
Keywords
γ-Glutamyltransferase ; Adiponectin ; Pulse wave velocity
Abstract
AIM: Serum γ-glutamyltransferase (GGT) is used as a marker of hepatic dysfunction. Recently, several studies reported that GGT is significantly associated with cardiovascular mortality and atherosclerosis. Adiponectin is known to play an important role in the development of atherosclerosis, but its physiologic role has yet to be fully determined. In this study, we investigated the relationships among serum GGT, adiponectin and arterial stiffness. METHODS: Of 4236 subjects recruited from 17 different medical centers in Seoul, Korea, 2846 subjects were enrolled in our study. The parameters of metabolic syndrome (MetS) were assessed in these subjects, and their plasma adiponectin levels and pulse wave velocity (PWV) were measured along with anthropometric and biochemical profiles, including GGT. RESULTS: The subjects were stratified into 3 groups according to GGT values. PWV values gradually increased and the adiponectin level decreased with GGT tertiles. Aortic PWV showed a significant correlation with age, SBP, FPG, but there was no correlation among aortic PWV, GGT and adiponectin. Peripheral PWV demonstrated a significant correlation with age, SBP, DBP, BMI, WC, FPG and GGT, but there was no correlation between peripheral PWV and adiponectin. In multiple logistic regression analysis after adjusting for risk factors, GGT was a significant contributor to increased peripheral PWV. CONCLUSIONS: These findings indicate that serum GGT is independently associated with increased arterial stiffness, but there was no correlation between adiponectin and arterial stiffness in both males and females.
Files in This Item:
T201203068.pdf Download
DOI
21986103
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Ae(강신애) ORCID logo https://orcid.org/0000-0002-9719-4774
Kim, Kyung Rae(김경래)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yoo, Jeong Seon(유정선)
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90618
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