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Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children

Authors
 Woo Kyung Kim  ;  Ji-Won Kwon  ;  Ju-Hee Seo  ;  Hyung Young Kim  ;  Jinho Yu  ;  Byoung-Ju Kim  ;  Hyo-Bin Kim  ;  So Yeon Lee  ;  Kyung Won Kim  ;  Mi-Jin Kang  ;  Yee-Jin Shin  ;  Soo-Jong Hong 
Citation
 JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol.130(2) : 421-5, 2012 
Journal Title
 JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 
ISSN
 0091-6749 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Antigens, Dermatophagoides/immunology* ; Carbachol/pharmacology ; Exocrine Glands/secretion* ; Female ; Humans ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Male ; Middle Aged ; Mucus/secretion ; Nasal Mucosa/secretion* ; Oligopeptides/pharmacology ; Piperazines/pharmacology ; Receptor, PAR-2/agonists ; Receptor, PAR-2/antagonists & inhibitors ; Receptor, PAR-2/immunology* ; Rhinitis, Allergic, Perennial/immunology* ; Allergens/immunology ; Child ; Construction Materials/adverse effects ; Environmental Exposure/adverse effects* ; Female ; Fungi/immunology* ; Genetic Predisposition to Disease ; Humans ; Infant ; Interleukin-13/genetics* ; Interleukin-13/immunology ; Male ; Odds Ratio ; Polymorphism, Genetic ; Prevalence ; Republic of Korea/epidemiology ; Rhinitis, Allergic, Perennial/epidemiology ; Rhinitis, Allergic, Perennial/etiology ; Rhinitis, Allergic, Perennial/genetics* ; Rhinitis, Allergic, Perennial/immunology ; Risk Factors ; Smoke/adverse effects ; Surveys and QuestionnairesYoung Adult
Keywords
Allergic rhinitis ; prevalence ; risk factor ; IL-13 polymorphism ; gene-environment interaction ; infancy
Abstract
BACKGROUND: The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors. OBJECTIVE: We analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect risk. METHODS: We used the International Study of Asthma and Allergies in Childhood questionnaire to collect data on AR, allergies, and environmental exposures from 4554 elementary school students from 5 areas of Seoul, Korea, in 2008. We also obtained DNA from 1050 subjects from 1 area of Seoul for genotype analysis of IL13. RESULTS: We identified genetic and environmental factors during infancy and early childhood that increased the risk for current AR (resulting in a diagnosis of AR and AR symptoms in the past 12 months) in elementary school-aged children. These included allergic disease in parents and antibiotic use in infants, allergic disease in parents and exposure of infants to mold, and allergic disease in parents and moving an infant to a newly built house. The risk of current AR also increased in subjects with GA or AA at nucleotide 2044 in IL13 who had been exposed to mold in the home during infancy (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11) compared with subjects who had GG at this position and had not been exposed to mold (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11). CONCLUSION: The prevalence of AR is increasing in Korean children. Children with a family history of allergic disease and exposure to specific environmental risk factors during infancy are more likely to have AR. Children with GA or AA at IL13(+2044) are at increased risk for AR when exposed to mold in the home during the first year of life.
Full Text
http://www.sciencedirect.com/science/article/pii/S0091674912008652
DOI
22846750
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90611
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