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Protease-activated receptor 2-dependent fluid secretion from airway submucosal glands by house dust mite extract

DC FieldValueLanguage
dc.contributor.author조형주-
dc.contributor.author최재영-
dc.contributor.author김규보-
dc.contributor.author김상철-
dc.contributor.author김유석-
dc.contributor.author김창훈-
dc.contributor.author윤주헌-
dc.contributor.author이정권-
dc.contributor.author이현재-
dc.date.accessioned2014-12-19T17:00:36Z-
dc.date.available2014-12-19T17:00:36Z-
dc.date.issued2012-
dc.identifier.issn0091-6749-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90609-
dc.description.abstractBACKGROUND: The submucosal gland (SMG) is important in the control of airway surface fluid. Protease-activated receptor (PAR) 2 contributes to the pathophysiology of allergies in response to nonspecific allergens bearing proteases and anion secretion. House dust mites (HDMs) have abundant proteases that can activate PAR2, but little is known about the direct effect of HDM on SMG secretion. OBJECTIVE: The aim of this study was to investigate the effect of HDMs on glandular secretion and its mechanism in allergic patients, patients with chronic rhinosinusitis (CRS), or both. METHODS: Inferior nasal turbinates were harvested from 55 patients and classified into 4 groups (the control, allergic rhinitis [AR], CRS, and AR+CRS groups). A microscope attached to a digital camera was used to quantify mucus bubbles from individual SMGs while stimulated with HDM extract, PAR2-activating peptide, and carbachol. PAR2 expression in the SMG was determined by means of immunostaining with anti-PAR2 mAb. RESULTS: HDM induced a significantly higher secretion rate and number of responding glands in the AR and AR+CRS groups than in the control group. Interestingly, patients in the CRS group, who had no HDM-specific IgE antibody, showed a higher response than the control group, and its response was suppressed by a PAR2-selective antagonist. The responses to PAR2-activating peptide were similar to those to HDM, and their secretion rates positively correlated with HDM responses. PAR2 was highly expressed in all 3 disease groups with immunostaining. CONCLUSIONS: HDM allergens can induce glandular secretion in patients with AR, CRS, or both, and PAR2 represents a possible mechanism for nonspecific hyperreactivity in inflammatory airway diseases.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntigens, Dermatophagoides/immunology*-
dc.subject.MESHCarbachol/pharmacology-
dc.subject.MESHExocrine Glands/secretion*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin E/blood-
dc.subject.MESHImmunoglobulin E/immunology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMucus/secretion-
dc.subject.MESHNasal Mucosa/secretion*-
dc.subject.MESHOligopeptides/pharmacology-
dc.subject.MESHPiperazines/pharmacology-
dc.subject.MESHReceptor, PAR-2/agonists-
dc.subject.MESHReceptor, PAR-2/antagonists & inhibitors-
dc.subject.MESHReceptor, PAR-2/immunology*-
dc.subject.MESHRhinitis, Allergic, Perennial/immunology*-
dc.subject.MESHSinusitis/immunology*-
dc.subject.MESHYoung Adult-
dc.titleProtease-activated receptor 2-dependent fluid secretion from airway submucosal glands by house dust mite extract-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorHyung-Ju Cho-
dc.contributor.googleauthorHyun Jae Lee-
dc.contributor.googleauthorSang Cheol Kim-
dc.contributor.googleauthorKyubo Kim-
dc.contributor.googleauthorYoo Suk Kim-
dc.contributor.googleauthorChang-Hoon Kim-
dc.contributor.googleauthorJeung-Gweon Lee-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.contributor.googleauthorJae Young Choi-
dc.identifier.doi22196772-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04173-
dc.contributor.localIdA01050-
dc.contributor.localIdA03936-
dc.contributor.localIdA00323-
dc.contributor.localIdA00529-
dc.contributor.localIdA00783-
dc.contributor.localIdA02604-
dc.contributor.localIdA03095-
dc.contributor.localIdA03293-
dc.relation.journalcodeJ01228-
dc.identifier.eissn1097-6825-
dc.identifier.pmid22196772-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S009167491101829X-
dc.subject.keywordHouse dust mites-
dc.subject.keywordsubmucosal gland-
dc.subject.keywordallergy-
dc.subject.keywordchronic rhinosinusitis-
dc.subject.keywordprotease-activated receptor-
dc.subject.keywordnasal-
dc.contributor.alternativeNameCho, Hyung Ju-
dc.contributor.alternativeNameChoi, Jae Young-
dc.contributor.alternativeNameKim, Kyu Bo-
dc.contributor.alternativeNameKim, Sang Cheol-
dc.contributor.alternativeNameKim, Yoo Suk-
dc.contributor.alternativeNameKim, Chang Hoon-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.alternativeNameLee, Jeung Gweon-
dc.contributor.alternativeNameLee, Hyun Jae-
dc.contributor.affiliatedAuthorChoi, Jae Young-
dc.contributor.affiliatedAuthorKim, Chang Hoon-
dc.contributor.affiliatedAuthorCho, Hyung Ju-
dc.contributor.affiliatedAuthorKim, Kyu Bo-
dc.contributor.affiliatedAuthorKim, Sang Cheol-
dc.contributor.affiliatedAuthorKim, Yoo Suk-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.contributor.affiliatedAuthorLee, Jeung Gweon-
dc.contributor.affiliatedAuthorLee, Hyun Jae-
dc.citation.volume129-
dc.citation.number2-
dc.citation.startPage529-
dc.citation.endPage535-
dc.identifier.bibliographicCitationJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol.129(2) : 529-535, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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