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Comparison of the response to treatment between Asian and Caucasian men with benign prostatic hyperplasia: long-term results from the combination of dutasteride and tamsulosin study.

Authors
 Byung-Ha Chung  ;  Seung Hwan Lee  ;  Claus G Roehrborn  ;  Paul F Siami  ;  Kim Major-Walker  ;  Timothy H Wilson 
Citation
 INTERNATIONAL JOURNAL OF UROLOGY, Vol.19(11) : 1031-1035, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF UROLOGY 
ISSN
 0919-8172 
Issue Date
2012
MeSH
5-alpha Reductase Inhibitors/administration & dosage ; 5-alpha Reductase Inhibitors/adverse effects ; 5-alpha Reductase Inhibitors/therapeutic use* ; Adrenergic alpha-1 Receptor Antagonists/administration & dosage ; Adrenergic alpha-1 Receptor Antagonists/adverse effects ; Adrenergic alpha-1 Receptor Antagonists/therapeutic use* ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Asian Continental Ancestry Group ; Azasteroids/administration & dosage ; Azasteroids/adverse effects ; Azasteroids/therapeutic use* ; Double-Blind Method ; Dutasteride ; European Continental Ancestry Group ; Humans ; Male ; Middle Aged ; Prostatic Hyperplasia/drug therapy* ; Sulfonamides/administration & dosage ; Sulfonamides/adverse effects ; Sulfonamides/therapeutic use* ; Treatment Outcome
Keywords
5-alpha Reductase Inhibitors/administration & dosage ; 5-alpha Reductase Inhibitors/adverse effects ; 5-alpha Reductase Inhibitors/therapeutic use* ; Adrenergic alpha-1 Receptor Antagonists/administration & dosage ; Adrenergic alpha-1 Receptor Antagonists/adverse effects ; Adrenergic alpha-1 Receptor Antagonists/therapeutic use* ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Asian Continental Ancestry Group ; Azasteroids/administration & dosage ; Azasteroids/adverse effects ; Azasteroids/therapeutic use* ; Double-Blind Method ; Dutasteride ; European Continental Ancestry Group ; Humans ; Male ; Middle Aged ; Prostatic Hyperplasia/drug therapy* ; Sulfonamides/administration & dosage ; Sulfonamides/adverse effects ; Sulfonamides/therapeutic use* ; Treatment Outcome
Abstract
The Combination of Avodart and Tamsulosin study was a 4-year, randomized, double-blind study of the efficacy and safety of dutasteride and tamsulosin, alone or in combination, in men with moderate-to-severe benign prostatic hyperplasia. In this post-hoc investigation, we analyzed primary and secondary end-points from the Combination of Avodart and Tamsulosin study in Asian (n = 325) and Caucasian men (n = 4259). The incidence of acute urinary retention or benign prostatic hyperplasia-related surgery did not differ significantly between treatment groups in the Asian subpopulation. In Caucasian men, the incidence of acute urinary retention/benign prostatic hyperplasia-related surgery was significantly lower in the combination therapy group compared with the tamsulosin monotherapy group (P < 0.001), but not compared with dutasteride monotherapy. Combination therapy significantly increased the time to benign prostatic hyperplasia clinical progression and resulted in improved International Prostate Symptom Score, maximum urinary flow rate, quality of life, and reduced prostate volume in Asian and Caucasian men who received combination therapy compared with tamsulosin monotherapy. Combination therapy also significantly improved (P < 0.05) time to benign prostatic hyperplasia clinical progression, International Prostate Symptom Score, maximum urinary flow rate and quality of life versus dutasteride in the Caucasian subpopulation. The adverse-event profile was comparable between subpopulations. In conclusion, Asian and Caucasian men respond similarly to these treatments, despite apparent racial differences in 5α-reductase activity.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1442-2042.2012.03091.x/abstract
DOI
22774774
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hwan(이승환) ORCID logo https://orcid.org/0000-0001-7358-8544
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90555
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