Cited 13 times in
High-dose helical tomotherapy with concurrent full-dose chemotherapy for locally advanced pancreatic cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 성진실 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 윤홍인 | - |
dc.contributor.author | 정윤선 | - |
dc.contributor.author | 장지석 | - |
dc.date.accessioned | 2014-12-19T16:58:04Z | - |
dc.date.available | 2014-12-19T16:58:04Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90530 | - |
dc.description.abstract | PURPOSE: To improve poor therapeutic outcome of current practice of chemoradiotherapy (CRT), high-dose helical tomotherapy (HT) with concurrent full-dose chemotherapy has been performed on patients with locally advanced pancreatic cancer (LAPC), and the results were analyzed. METHODS AND MATERIALS: We retrospectively reviewed 39 patients with LAPC treated with radiotherapy using HT (median, 58.4 Gy; range, 50.8-59.9 Gy) and concomitant chemotherapy between 2006 and 2009. Radiotherapy was directed to the primary tumor with a 0.5-cm margin without prophylactic nodal coverage. Twenty-nine patients (79%) received full-dose (1000 mg/m(2)) gemcitabine-based chemotherapy during HT. After completion of CRT, maintenance chemotherapy was administered to 37 patients (95%). RESULTS: The median follow-up was 15.5 months (range, 3.4-43.9) for the entire cohort, and 22.5 months (range, 12.0-43.9) for the surviving patients. The 1- and 2-year local progression-free survival rates were 82.1% and 77.3%, respectively. Eight patients (21%) were converted to resectable status, including 1 with a pathological complete response. The median overall survival and progression-free survival were 21.2 and 14.0 months, respectively. Acute toxicities were acceptable with no gastrointestinal (GI) toxicity higher than Grade 3. Severe late GI toxicity (≥ Grade 3) occurred in 10 patients (26%); 1 treatment-related death from GI bleeding was observed. CONCLUSION: High-dose helical tomotherapy with concurrent full-dose chemotherapy resulted in improved local control and long-term survival in patients with LAPC. Future studies are needed to widen the therapeutic window by minimizing late GI toxicity. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/adverse effects | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | Chemoradiotherapy/adverse effects | - |
dc.subject.MESH | Chemoradiotherapy/methods* | - |
dc.subject.MESH | Cisplatin/administration & dosage | - |
dc.subject.MESH | Deoxycytidine/administration & dosage | - |
dc.subject.MESH | Deoxycytidine/analogs & derivatives | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oxonic Acid/administration & dosage | - |
dc.subject.MESH | Pancreatic Neoplasms/mortality | - |
dc.subject.MESH | Pancreatic Neoplasms/pathology | - |
dc.subject.MESH | Pancreatic Neoplasms/therapy* | - |
dc.subject.MESH | Radiotherapy Dosage | - |
dc.subject.MESH | Radiotherapy, Intensity-Modulated/adverse effects | - |
dc.subject.MESH | Radiotherapy, Intensity-Modulated/methods* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tegafur/administration & dosage | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | High-dose helical tomotherapy with concurrent full-dose chemotherapy for locally advanced pancreatic cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Michael L.C. Wang | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.contributor.googleauthor | Yoonsun Chung | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.identifier.doi | 10.1016/j.ijrobp.2011.10.050 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A01956 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03678 | - |
dc.contributor.localId | A04777 | - |
dc.contributor.localId | A04658 | - |
dc.relation.journalcode | J01157 | - |
dc.identifier.eissn | 1879-355X | - |
dc.identifier.pmid | 22285669 | - |
dc.identifier.pmid | 22285669 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0360301611034584 | - |
dc.subject.keyword | Locally advanced pancreatic cancer | - |
dc.subject.keyword | Radiotherapy | - |
dc.subject.keyword | Helical tomotherapy | - |
dc.subject.keyword | Patterns of failure | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.alternativeName | Yoon, Hong In | - |
dc.contributor.alternativeName | Chung, Yoon Sun | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Chung, Yoon Sun | - |
dc.contributor.affiliatedAuthor | Yoon, Hong In | - |
dc.citation.volume | 83 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1448 | - |
dc.citation.endPage | 1454 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.83(5) : 1448-1454, 2012 | - |
dc.identifier.rimsid | 32819 | - |
dc.type.rims | ART | - |
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