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Co-treatment with retinyl retinoate and a PPARα agonist reduces retinoid dermatitis.

Authors
 Bora Kim  ;  Jin E. Kim  ;  Hyuk Kim  ;  Joo D. Lee  ;  Kang-Yell Choi  ;  Seung H. Lee 
Citation
 INTERNATIONAL JOURNAL OF DERMATOLOGY, Vol.51(6) : 733-741, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF DERMATOLOGY 
ISSN
 0011-9059 
Issue Date
2012
MeSH
Administration, Topical ; Animals ; Cell Differentiation ; Cell Proliferation ; Dermatitis/drug therapy* ; Dermatitis/pathology ; Enzyme Inhibitors/pharmacology ; Epidermis/pathology ; Female ; Interleukin-1alpha/genetics ; Interleukin-1alpha/metabolism ; Interleukin-8/genetics ; Interleukin-8/metabolism ; Keratolytic Agents/adverse effects ; Liver X Receptors ; Mice ; Mice, Hairless ; Orphan Nuclear Receptors/agonists ; PPAR alpha/agonists* ; Palmitic Acid/pharmacology ; Pyrimidines/pharmacology ; RNA, Messenger/metabolism ; Retinoids/adverse effects* ; Tretinoin/adverse effects* ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Water Loss, Insensible
Keywords
Administration, Topical ; Animals ; Cell Differentiation ; Cell Proliferation ; Dermatitis/drug therapy* ; Dermatitis/pathology ; Enzyme Inhibitors/pharmacology ; Epidermis/pathology ; Female ; Interleukin-1alpha/genetics ; Interleukin-1alpha/metabolism ; Interleukin-8/genetics ; Interleukin-8/metabolism ; Keratolytic Agents/adverse effects ; Liver X Receptors ; Mice ; Mice, Hairless ; Orphan Nuclear Receptors/agonists ; PPAR alpha/agonists* ; Palmitic Acid/pharmacology ; Pyrimidines/pharmacology ; RNA, Messenger/metabolism ; Retinoids/adverse effects* ; Tretinoin/adverse effects* ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Water Loss, Insensible
Abstract
BACKGROUND:   Retinoids have been used for the treatment of skin disorders such as acne, psoriasis, and photoaging. However, despite their beneficial effects, topical retinoids often cause severe local irritation called retinoid dermatitis. We previously developed a novel vitamin A derivative, retinyl retinoate, which induces less irritation and affords excellent tolerance. In this study, we examined whether co-treatment with topical peroxisome proliferator-activated receptor-α (PPARα) agonists (e.g. WY14643) reduce retinoid dermatitis in hairless mouse skin. METHODS:   The effect of concomitant treatment with a PPARα agonist on retinoid dermatitis in hairless mouse epidermis was evaluated by measuring transepidermal water loss, epidermal histology, and cytokine expression. RESULTS:   Retinyl retinoate induced less severe retinoid dermatitis than retinoic acid. Topical application of a PPARα agonist improved the stratum corneum structure and function, reduced mRNA expression of interleukin (IL)-1α, tumor necrosis factor-α and IL-8, and inhibited ear edema induced by retinoic acid or retinyl retinoate. CONCLUSIONS:   Our results indicate that PPARα agonists can potentially be used to improve retinoid dermatitis. We suggest that co-treatment with retinyl retinoate and a PPARα agonist may reduce or prevent detrimental alterations in retinoid-treated skin.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-4632.2011.05332.x/abstract
DOI
22607296
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hun(이승헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90472
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