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Modeling of the LDL cholesterol-lowering effect of atorvastatin in Korean dyslipidemic patients and non-patient volunteers.

DC Field Value Language
dc.contributor.author박경수-
dc.contributor.author박민수-
dc.contributor.author이상학-
dc.contributor.author정재용-
dc.date.accessioned2014-12-19T16:56:00Z-
dc.date.available2014-12-19T16:56:00Z-
dc.date.issued2012-
dc.identifier.issn0946-1965-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90464-
dc.description.abstractOBJECTIVE: The aim of this study was to develop a longitudinal pharmacodynamic model describing the time-courses of low-density lipoprotein cholesterol (LDL) profiles during and after atorvastatin treatment in Korean dyslipidemic patients and non-patient volunteers. METHODS: 15 dyslipidemic patients and 11 non-patient volunteers with no prior therapy participated in a parallel, 2-step dose escalation study. Subjects received atorvastatin doses ranging from 10 to 80 mg for 42 days (dyslipidemic patients) or 10 mg for 21 days (non-patient volunteers). Plasma samples were collected before and during the treatment period and up to 2 weeks after the last administration. A population pharmacodynamic model was built using the NONMEM software package. An indirect response model consisting of production in hepatocyte and elimination from plasma stimulated by atorvastatin described the LDL time-course. RESULTS: The typical population value of the estimated dose producing 50% of maximal stimulation on LDL elimination (SD50) for dyslipidemic patients was 11.9 mg, which was about 6 times higher than that of non-patient volunteers (2.0 mg). CONCLUSION: A longitudinal population pharmacodynamic model for the LDL-lowering effect of atorvastatin in both dyslipidemic patients and non-patient volunteers was developed. This could help guide optimal therapies according to the target population.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAsian Continental Ancestry Group*-
dc.subject.MESHAtorvastatin Calcium-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHCholesterol, LDL/blood*-
dc.subject.MESHComputer Simulation-
dc.subject.MESHDecision Support Techniques-
dc.subject.MESHDown-Regulation-
dc.subject.MESHDrug Administration Schedule-
dc.subject.MESHDrug Dosage Calculations-
dc.subject.MESHDyslipidemias/blood-
dc.subject.MESHDyslipidemias/drug therapy*-
dc.subject.MESHDyslipidemias/ethnology-
dc.subject.MESHFemale-
dc.subject.MESHHeptanoic Acids/administration & dosage-
dc.subject.MESHHeptanoic Acids/blood-
dc.subject.MESHHeptanoic Acids/pharmacokinetics*-
dc.subject.MESHHumans-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/blood-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHModels, Biological*-
dc.subject.MESHPyrroles/administration & dosage-
dc.subject.MESHPyrroles/blood-
dc.subject.MESHPyrroles/pharmacokinetics*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleModeling of the LDL cholesterol-lowering effect of atorvastatin in Korean dyslipidemic patients and non-patient volunteers.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorEun Sil Oh-
dc.contributor.googleauthorSang-Hak Lee-
dc.contributor.googleauthorMin Soo Park-
dc.contributor.googleauthorKyungsoo Park-
dc.contributor.googleauthorJae-Yong Chung-
dc.identifier.doi22981146-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01422-
dc.contributor.localIdA01468-
dc.contributor.localIdA03709-
dc.contributor.localIdA02833-
dc.relation.journalcodeJ01098-
dc.identifier.pmid22981146-
dc.identifier.urlhttp://www.dustri.com/index.php?id=98&artId=9968-
dc.subject.keywordmodeling-
dc.subject.keywordLDL-lowering-
dc.subject.keywordpharmacodynamics-
dc.subject.keywordatorvastatin-
dc.subject.keywordNONMEM-
dc.contributor.alternativeNamePark, Kyung Soo-
dc.contributor.alternativeNamePark, Min Soo-
dc.contributor.alternativeNameLee, Sang Hak-
dc.contributor.alternativeNameChung, Jae Yong-
dc.contributor.affiliatedAuthorPark, Kyung Soo-
dc.contributor.affiliatedAuthorPark, Min Soo-
dc.contributor.affiliatedAuthorChung, Jae Yong-
dc.contributor.affiliatedAuthorLee, Snag Hak-
dc.citation.volume50-
dc.citation.number9-
dc.citation.startPage647-
dc.citation.endPage656-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, Vol.50(9) : 647-656, 2012-
dc.identifier.rimsid32780-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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