0 478

Cited 0 times in

Percent tumor volume predicts biochemical recurrence after radical prostatectomy: multi-institutional data analysis.

Authors
 Cheryn Song  ;  Seongil Seo  ;  Hanjong Ahn  ;  Seok-Soo Byun  ;  Jin Seon Cho  ;  Young Deuk Choi  ;  Eunsik Lee  ;  Hyun Moo Lee  ;  Sang Eun Lee  ;  Han Yong Choi 
Citation
 INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, Vol.17(4) : 355-360, 2012 
Journal Title
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
ISSN
 1341-9625 
Issue Date
2012
MeSH
Adult ; Aged ; Disease-Free Survival ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Prostate-Specific Antigen/blood* ; Prostatectomy/methods* ; Prostatic Neoplasms*/blood ; Prostatic Neoplasms*/pathology ; Prostatic Neoplasms*/surgery ; Recurrence ; Tumor Burden*
Keywords
Prostate cancer ; Radical prostatectomy ; Tumor volume ; Surgical margin ; Biochemical recurrence-free survival
Abstract
BACKGROUND: To investigate the prognostic significance of percent tumor volume (PTV) in relation to the surgical margin status in men with prostate cancer after radical prostatectomy (RP).

METHODS: Clinical and pathological data from 1,567 patients treated with RP only between 1995 and 2007 at participating institutions were reviewed. PTV was determined by the sum of all visually estimated tumor foci on every section. Biochemical recurrence (BCR) was defined as 2 consecutive increases in prostate-specific antigen (PSA) > 0.2 ng/ml and various clinicopathological variables were tested for prognostication of recurrence-free survival.

RESULTS: Serum PSA at surgery was 12.5 ± 16.8 ng/ml and pathological stage was T2 in 899 (57.4%) patients. Surgical Gleason score was 7 in 842 patients (53.7%), higher than 7 in 250 (16%) patients, and in 32% of the patients, surgical margin was positive. Mean PTV was 15.7% and demonstrated a significant positive correlation with serum PSA, all pathological variables and BCR. On multivariate analysis, preoperative PSA (p = 0.012), surgical Gleason score (p < 0.0001, HR 2.183, 95% CI 1.778-2.681), and PTV (≤5, 5.1-15, >15%; p < 0.0001, HR 1.393, 95% CI 1.183-1.641) were independently prognostic of recurrence-free survival. Pathological stage demonstrated a significant relationship with BCR but was not independently prognostic in the multivariate model.

CONCLUSION: In men with prostate cancer, preoperative PSA, surgical Gleason score, and PTV are independent predictors of recurrence-free survival after RP.
Full Text
http://link.springer.com/article/10.1007%2Fs10147-011-0295-2
DOI
21818571
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90461
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links