Cited 10 times in
A multiplicity of anti-invasive effects of farnesyl transferase inhibitor SCH66336 in human head and neck cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이옥희 | - |
dc.date.accessioned | 2014-12-19T16:55:21Z | - |
dc.date.available | 2014-12-19T16:55:21Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90444 | - |
dc.description.abstract | Metastasis is a critical event in the progression of head and neck squamous cell carcinoma (HNSCC) and closely correlates with clinical outcome. We previously showed that the farnesyl transferase inhibitor SCH66336 has antitumor activities in HNSCC by inducing insulin-like growth factor binding protein 3 (IGFBP-3) secretion, which in turn inhibits tumor growth and angiogenesis. In this study, we found that SCH66336 at a sublethal dose for HNSCC inhibited the migration and invasion of HNSCC cells. The inhibitory effect of SCH66336 was associated with the blockade of the IGF-1 receptor (IGF-1R) pathway via suppressing IGF-1R itself and Akt expression. Consistent with previous work, induction of IGFBP-3 by SCH66336 also contributed in part to the anti-invasive effect. SCH66336 treatment also reduced the expression and activity of the urokinase-type plasminogen activator (uPA) and matrix metalloproteinase 2 (MMP-2), both important regulators of tumor metastasis. The effect of SCH66336 on uPA activity was inhibited partly by knockdown of IGFBP-3 using siRNA. The inhibitory effect of SCH66336 on migration or invasion was attenuated partly or completely by knockdown of IGFBP-3, Akt, or IGF-1R expression, respectively. Our results demonstrate that the IGF-1R pathway plays a major role in the proliferation, migration, and invasion of HNSCC cells, suggesting that therapeutic obstruction of the IGF-1R pathway would be a useful approach to treating patients with HNSCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carcinoma, Squamous Cell/metabolism | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Movement/drug effects | - |
dc.subject.MESH | Farnesyltranstransferase/antagonists & inhibitors* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Head and Neck Neoplasms/metabolism | - |
dc.subject.MESH | Head and Neck Neoplasms/pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin-Like Growth Factor Binding Protein 3/genetics | - |
dc.subject.MESH | Insulin-Like Growth Factor Binding Protein 3/metabolism* | - |
dc.subject.MESH | Matrix Metalloproteinase 2/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Piperidines/pharmacology* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.MESH | Pyridines/pharmacology* | - |
dc.subject.MESH | RNA Interference | - |
dc.subject.MESH | RNA, Small Interfering | - |
dc.subject.MESH | Receptor, IGF Type 1/antagonists & inhibitors | - |
dc.subject.MESH | Receptor, IGF Type 1/genetics | - |
dc.subject.MESH | Receptor, IGF Type 1/metabolism | - |
dc.subject.MESH | Urokinase-Type Plasminogen Activator/metabolism | - |
dc.title | A multiplicity of anti-invasive effects of farnesyl transferase inhibitor SCH66336 in human head and neck cancer | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) | - |
dc.contributor.googleauthor | Seung Hyun Oh | - |
dc.contributor.googleauthor | Ju-Hee Kang | - |
dc.contributor.googleauthor | Jong Kyu Woo | - |
dc.contributor.googleauthor | Ok-Hee Lee | - |
dc.contributor.googleauthor | Edward S. Kim | - |
dc.contributor.googleauthor | Ho-Young Lee | - |
dc.identifier.doi | 10.1002/ijc.26373 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02970 | - |
dc.relation.journalcode | J01092 | - |
dc.identifier.eissn | 1097-0215 | - |
dc.identifier.pmid | 22113431 | - |
dc.subject.keyword | insulin-like growth factor binding protein-3 | - |
dc.subject.keyword | insulin-like growth factor-1 receptor | - |
dc.subject.keyword | farnesyl transferase inhibitor | - |
dc.subject.keyword | head and neck squamous cell carcinoma | - |
dc.subject.keyword | invasion | - |
dc.subject.keyword | SCH66336 | - |
dc.contributor.alternativeName | Lee, Ok Hee | - |
dc.contributor.affiliatedAuthor | Lee, Ok Hee | - |
dc.citation.volume | 131 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 537 | - |
dc.citation.endPage | 547 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CANCER, Vol.131(3) : 537-547, 2012 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.