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The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus.

Authors
 Jin Ha Lee  ;  Tae Il Kim  ;  Soung Min Jeon  ;  Sung Pil Hong  ;  Jae Hee Cheon  ;  Won Ho Kim 
Citation
 INTERNATIONAL JOURNAL OF CANCER, Vol.131(3) : 752-759, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF CANCER 
ISSN
 0020-7136 
Issue Date
2012
MeSH
Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/mortality* ; Diabetes Complications* ; Diabetes Mellitus ; Female ; Humans ; Hypoglycemic Agents/therapeutic use* ; Male ; Metformin/therapeutic use* ; Middle Aged ; Survival Rate ; Treatment Outcome
Keywords
colorectal cancer ; diabetes mellitus ; metformin ; survival
Abstract
Metformin use has been associated with decreased cancer risk and mortality. However, the effects of metformin on clinical outcomes of colorectal cancer (CRC) are not defined. This study aimed to evaluate the association between metformin use and mortality of CRC in diabetic patients. We identified 595 patients who were diagnosed both CRC and diabetes mellitus. Patients were compared by two groups; 258 diabetic patients taking metformin and 337 diabetic patients not taking metformin. Patient's demographics, clinical characteristics, overall mortality and CRC-specific mortality were analyzed. After a median follow-up of 41 months, there were 71 total deaths (27.5%) and 55 CRC-specific deaths (21.3%) among 258 patients who used metformin, compared with 136 total deaths (40.4%) and 104 CRC-specific deaths (30.9%) among 337 patients who did not use metformin. Metformin use was associated with decreased overall mortality (p = 0.018) and CRC-specific mortality (p = 0.042) by univariate analysis. After adjustment for clinically relevant factors, metformin use showed lower risk of overall mortality (HR, 0.66; 95% CI 0.476-0.923; p = 0.015) and CRC-specific mortality (HR, 0.66; 95% CI 0.45-0.975; p = 0.037) in CRC patients with diabetes. Metformin use in CRC patients with diabetes is associated with lower risk of CRC-specific and overall mortality.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ijc.26421/abstract
DOI
21913184
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Jeon, Soung Min(전승민)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90441
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