3 316

Cited 0 times in

Exposure to gene-environment interactions before 1 year of age may favor the development of atopic dermatitis.

Authors
 Lee J.-Y.  ;  Seo J.-H.  ;  Kwon J.-W.  ;  Yu J.  ;  Kim B.-J.  ;  Lee S.-Y.  ;  Kim H.-B.  ;  Kim W.-K.  ;  Kim K.-W.  ;  Shin Y.-J.  ;  Hong S.-J. 
Citation
 INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, Vol.157(4) : 363-371, 2012 
Journal Title
 INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 
ISSN
 1018-2438 
Issue Date
2012
MeSH
Adolescent ; Child ; Dermatitis, Atopic/epidemiology* ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/genetics* ; Dermatitis, Atopic/immunology ; Environmental Exposure/adverse effects ; Female ; Gene-Environment Interaction ; Humans ; Infant ; Infant, Newborn ; Korea ; Male ; Prevalence ; Risk Factors ; Schools ; Surveys and Questionnaires
Keywords
Atopic dermatitis ; Gene-environment interaction ; Prevalence ; Risk factor
Abstract
BACKGROUND: The aims of this study were to determine (1) the prevalence of atopic dermatitis (AD) in Seoul, Korea, and (2) the influence of environmental and genetic factors on disease risk. METHODS: A questionnaire survey was conducted in 5,036 primary school children and 4,607 middle school children in 2008. For each child, a modified version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and a questionnaire assessing exposure to environmental variables were completed. RESULTS: In primary school children, the lifetime prevalence of itchy eczema was 24.3%, the 12-month prevalence of itchy flexural eczema was 18.0%, the lifetime prevalence of AD diagnosis was 31.3%, and the 12-month prevalence of AD treatment was 14.5%. In middle school children, the corresponding rates were 16.0, 10.8, 22.1, and 8.3%, respectively. These rates are significantly higher than those reported in similar studies conducted in 1995 and 2000. In both primary and middle school children, a parental history of allergic disease and a history of having moved into a newly built house before 1 year of age were independently associated with a risk for current AD. For current AD, the prevalence odds ratio was higher in the subgroup with both a genetic and a specific environmental risk factor than in the subgroup with no risk factor or subgroups with only one risk factor. CONCLUSIONS: The prevalence of AD in primary and middle school children in Seoul has increased. Its development may be influenced by gene-environment interactions, particularly before 1 year of age.
Full Text
http://www.karger.com/Article/FullText/328778
DOI
22123373
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90424
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links