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Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products.

DC Field Value Language
dc.contributor.author송경주-
dc.contributor.author신명헌-
dc.contributor.author이영아-
dc.contributor.author김경아-
dc.contributor.author남영희-
dc.contributor.author민아림-
dc.date.accessioned2014-12-19T16:54:17Z-
dc.date.available2014-12-19T16:54:17Z-
dc.date.issued2012-
dc.identifier.issn1023-3830-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90411-
dc.description.abstractOBJECTIVE AND METHOD: Trichomonas vaginalis is a flagellated protozoan parasite that causes human trichomoniasis. Although T. vaginalis itself can secrete lipid mediator leukotriene (LT) B(4) leading to neutrophil activation, information regarding the signaling mechanism involved in neutrophil activation induced by T. vaginalis-secreted LTB(4) is limited. We investigated whether LTB(4) contained in the T. vaginalis-derived secretory products (TvSP) is closely involved in interleukin (IL)-8 production in human neutrophils via LTB(4) receptors BLT1 or BLT2. RESULTS: T. vaginalis produced more than 714 pg/ml of LTB(4) per 1 × 10(7) trichomonads. The ability of trichomonads to secrete LTB(4) was inhibited by treatment of trichomonads with the 5-lipo-oxygenease inhibitor AA861, but not the cyclo-oxygenease I inhibitor FR122047. When neutrophils were incubated with TvSP obtained from 1 × 10(7) trichomonads, IL-8 protein secretion was significantly increased compared to results for cells incubated with medium alone. The stimulatory effect of TvSP on IL-8 production was strongly inhibited by pretreatment of TvSP with lipase, although pretreatment with heat or proteinase K showed little inhibitory effect. Moreover, TvSP-induced IL-8 production was efficiently inhibited when trichomonads were pretreated with AA861 or when neutrophils were pretreated with antagonists for BLT1 or BLT2. CONCLUSION: Our results suggest that LTB(4) receptors BLT1 and BLT2 are involved in IL-8 production in neutrophils induced by T. vaginalis.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINFLAMMATION RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBenzoquinones/pharmacology-
dc.subject.MESHEndopeptidase K/pharmacology-
dc.subject.MESHFatty Alcohols/pharmacology-
dc.subject.MESHGlycols/pharmacology-
dc.subject.MESHHot Temperature-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-8/biosynthesis-
dc.subject.MESHInterleukin-8/immunology*-
dc.subject.MESHInterleukin-8/secretion-
dc.subject.MESHLeukotriene Antagonists/pharmacology-
dc.subject.MESHLeukotriene B4/analysis-
dc.subject.MESHLipase/pharmacology-
dc.subject.MESHLipoxygenase Inhibitors/pharmacology-
dc.subject.MESHNeutrophil Activation/drug effects-
dc.subject.MESHNeutrophil Activation/immunology-
dc.subject.MESHNeutrophils/drug effects-
dc.subject.MESHNeutrophils/immunology*-
dc.subject.MESHNeutrophils/parasitology-
dc.subject.MESHPiperazines/pharmacology-
dc.subject.MESHReceptors, Leukotriene B4/antagonists & inhibitors-
dc.subject.MESHReceptors, Leukotriene B4/immunology*-
dc.subject.MESHTetrazoles/pharmacology-
dc.subject.MESHThiazoles/pharmacology-
dc.subject.MESHTrichomonas Infections/immunology*-
dc.subject.MESHTrichomonas Infections/parasitology-
dc.subject.MESHTrichomonas vaginalis/drug effects-
dc.subject.MESHTrichomonas vaginalis/immunology*-
dc.titleLeukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Environmental Medical Biology (환경의생물학)-
dc.contributor.googleauthorYoung Hee Nam-
dc.contributor.googleauthorArim Min-
dc.contributor.googleauthorSeong Hoon Kim-
dc.contributor.googleauthorYoung Ah Lee-
dc.contributor.googleauthorKyeong Ah Kim-
dc.contributor.googleauthorKyoung-Ju Song-
dc.contributor.googleauthorMyeong Heon Shin-
dc.identifier.doi22215047-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02012-
dc.contributor.localIdA02099-
dc.contributor.localIdA02959-
dc.contributor.localIdA01258-
dc.contributor.localIdA01405-
dc.contributor.localIdA00300-
dc.relation.journalcodeJ01059-
dc.identifier.eissn1420-908X-
dc.identifier.pmid22215047-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00011-011-0425-3-
dc.subject.keywordTrichomonas vaginalis-
dc.subject.keywordHuman neutrophils-
dc.subject.keywordIL-8-
dc.subject.keywordLeukotriene B4 receptors BLT1-
dc.subject.keywordBLT2-
dc.contributor.alternativeNameSong, Kyoung Ju-
dc.contributor.alternativeNameShin, Myeong Heon-
dc.contributor.alternativeNameLee, Young Ah-
dc.contributor.alternativeNameKim, Kyung Ah-
dc.contributor.alternativeNameNam, Young Hee-
dc.contributor.alternativeNameMin, A Rim-
dc.contributor.affiliatedAuthorSong, Kyoung Ju-
dc.contributor.affiliatedAuthorShin, Myeong Heon-
dc.contributor.affiliatedAuthorLee, Young Ah-
dc.contributor.affiliatedAuthorNam, Young Hee-
dc.contributor.affiliatedAuthorMin, A Rim-
dc.contributor.affiliatedAuthorKim, Kyung Ah-
dc.citation.volume61-
dc.citation.number2-
dc.citation.startPage97-
dc.citation.endPage102-
dc.identifier.bibliographicCitationINFLAMMATION RESEARCH, Vol.61(2) : 97-102, 2012-
dc.identifier.rimsid34201-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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