Cited 4 times in
Anti-inflammatory, antinociceptive and anti-angiogenic activities of a phospholipid mixture purified from porcine lung tissues
DC Field | Value | Language |
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dc.contributor.author | 이종은 | - |
dc.date.accessioned | 2014-12-19T16:53:37Z | - |
dc.date.available | 2014-12-19T16:53:37Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0892-3973 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90391 | - |
dc.description.abstract | This work aimed to assess anti-inflammatory and related properties of a phospholipid mixture purified from porcine lung tissues, named KT&G101, which is being developed as a novel topical remedy for atopic dermatitis. KT&G101 consists of pure phospholipids, mainly phosphatidylcholine (PC) and other phospholipids such as phosphatidylinositol (PI) and phosphatidylserine (PS). Its predominant PC species is 1,2-dipalmitoylphosphatidylcholine (DPPC). KT&G101 exhibited an anti-angiogenic activity in the chick chorioallantoic membrane (CAM) assay. Oral administration of KT&G101 at the dosages of 100, 200 and 400 mg/kg body weight gave rise to an inhibition of 15.4%, 25.3% and 30.1% in the vascular permeability assay, respectively. In the carrageenan-induced inflammation in the air pouches, KT&G101 significantly diminished the volume of exudates in the pouches, the number of polymorphonuclear leukocytes and nitrite content in exudates. In the acetic acid-induced writhing response, oral administration of KT&G101 at the dosages of 50, 100 and 200 mg/kg body weight showed the reduction of 21.6%, 51.6% and 60.8% in the pain response of mice, respectively. It was also able to diminish the nitric oxide (NO) and reactive oxygen species (ROS) levels in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. KT&G101 displayed a significant suppression on the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the stimulated RAW264.7 cells. However, the free radical scavenging activity of KT&G101 was detected to be very weak in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Taken together, KT&G101 possesses anti-inflammatory and related antinociceptive and anti-angiogenic activities, which indirectly supports its use as an anti-atopic therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Analgesics*/chemistry | - |
dc.subject.MESH | Analgesics*/isolation & purification | - |
dc.subject.MESH | Analgesics*/pharmacology | - |
dc.subject.MESH | Angiogenesis Inhibitors*/chemistry | - |
dc.subject.MESH | Angiogenesis Inhibitors*/isolation & purification | - |
dc.subject.MESH | Angiogenesis Inhibitors*/pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Inflammatory Agents*/chemistry | - |
dc.subject.MESH | Anti-Inflammatory Agents*/isolation & purification | - |
dc.subject.MESH | Anti-Inflammatory Agents*/pharmacology | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Chick Embryo | - |
dc.subject.MESH | Dermatitis, Atopic/drug therapy* | - |
dc.subject.MESH | Dermatitis, Atopic/immunology | - |
dc.subject.MESH | Dermatitis, Atopic/metabolism | - |
dc.subject.MESH | Dermatitis, Atopic/pathology | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Lipopolysaccharides/pharmacology | - |
dc.subject.MESH | Lung/chemistry* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Neutrophils/immunology | - |
dc.subject.MESH | Neutrophils/metabolism | - |
dc.subject.MESH | Neutrophils/pathology | - |
dc.subject.MESH | Nitric Oxide/immunology | - |
dc.subject.MESH | Nitric Oxide/metabolism | - |
dc.subject.MESH | Phospholipids*/chemistry | - |
dc.subject.MESH | Phospholipids*/isolation & purification | - |
dc.subject.MESH | Phospholipids*/pharmacology | - |
dc.subject.MESH | Reactive Oxygen Species/immunology | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.subject.MESH | Swine | - |
dc.title | Anti-inflammatory, antinociceptive and anti-angiogenic activities of a phospholipid mixture purified from porcine lung tissues | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Hyun-Joo Jung | - |
dc.contributor.googleauthor | Jeong-Su Moon | - |
dc.contributor.googleauthor | A Rum Park | - |
dc.contributor.googleauthor | Hojin Choi | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.contributor.googleauthor | Seong-Hyun Choi | - |
dc.contributor.googleauthor | Chang-Jin Lim | - |
dc.identifier.doi | 10.3109/08923973.2011.611137 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03146 | - |
dc.relation.journalcode | J01039 | - |
dc.identifier.eissn | 1532-2513 | - |
dc.identifier.pmid | 21981117 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/08923973.2011.611137 | - |
dc.subject.keyword | Phospholipid | - |
dc.subject.keyword | anti-inflammatory | - |
dc.subject.keyword | antinociceptive | - |
dc.subject.keyword | anti-angiogenic | - |
dc.subject.keyword | cyclooxygenase-2 | - |
dc.subject.keyword | inducible nitric oxide synthase | - |
dc.subject.keyword | nitric oxide | - |
dc.subject.keyword | reactive oxygen species | - |
dc.contributor.alternativeName | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Jong Eun | - |
dc.citation.volume | 34 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 398 | - |
dc.citation.endPage | 407 | - |
dc.identifier.bibliographicCitation | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, Vol.34(3) : 398-407, 2012 | - |
dc.identifier.rimsid | 34185 | - |
dc.type.rims | ART | - |
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