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miR-200b regulates cell migration via Zeb family during mouse palate development.

DC FieldValueLanguage
dc.contributor.author김은정-
dc.contributor.author나까가와에이죠-
dc.contributor.author신정오-
dc.contributor.author이종민-
dc.contributor.author정한성-
dc.contributor.author조경원-
dc.contributor.author조성원-
dc.date.accessioned2014-12-19T16:52:56Z-
dc.date.available2014-12-19T16:52:56Z-
dc.date.issued2012-
dc.identifier.issn0948-6143-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90371-
dc.description.abstractPalate development requires coordinating proper cellular and molecular events in palatogenesis, including the epithelial-mesenchymal transition (EMT), apoptosis, cell proliferation, and cell migration. Zeb1 and Zeb2 regulate epithelial cadherin (E-cadherin) and EMT during organogenesis. While microRNA 200b (miR-200b) is known to be a negative regulator of Zeb1 and Zeb2 in cancer progression, its regulatory effects on Zeb1 and Zeb2 in palatogenesis have not yet been clarified. The aim of this study is to investigate the relationship between the regulators of palatal development, specifically, miR-200b and the Zeb family. Expression of both Zeb1 and Zeb2 was detected in the mesenchyme of the mouse palate, while miR-200b was expressed in the medial edge epithelium. After contact with the palatal shelves, miR-200b was expressed in the palatal epithelial lining and epithelial island around the fusion region but not in the palatal mesenchyme. The function of miR-200b was examined by overexpression via a lentiviral vector in the palatal shelves. Ectopic expression of miR-200b resulted in suppression of the Zeb family, upregulation of E-cadherin, and changes in cell migration and palatal fusion. These results suggest that miR-200b plays crucial roles in cell migration and palatal fusion by regulating Zeb1 and Zeb2 as a noncoding RNA during palate development.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfHISTOCHEMISTRY AND CELL BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCadherins/genetics-
dc.subject.MESHCadherins/metabolism-
dc.subject.MESHCell Movement*-
dc.subject.MESHCells, Cultured-
dc.subject.MESHEpithelial-Mesenchymal Transition-
dc.subject.MESHHomeodomain Proteins/genetics-
dc.subject.MESHHomeodomain Proteins/metabolism*-
dc.subject.MESHKruppel-Like Transcription Factors/genetics-
dc.subject.MESHKruppel-Like Transcription Factors/metabolism*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHMicroRNAs/genetics-
dc.subject.MESHMicroRNAs/metabolism*-
dc.subject.MESHPalate/embryology*-
dc.subject.MESHPalate/metabolism*-
dc.subject.MESHRepressor Proteins/genetics-
dc.subject.MESHRepressor Proteins/metabolism*-
dc.subject.MESHZinc Finger E-box Binding Homeobox 2-
dc.subject.MESHZinc Finger E-box-Binding Homeobox 1-
dc.titlemiR-200b regulates cell migration via Zeb family during mouse palate development.-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorJeong-Oh Shin-
dc.contributor.googleauthorEizo Nakagawa-
dc.contributor.googleauthorEun-Jung Kim-
dc.contributor.googleauthorKyoung-Won Cho-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorSung-Won Cho-
dc.contributor.googleauthorHan-Sung Jung-
dc.identifier.doi22261924-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01228-
dc.contributor.localIdA03758-
dc.contributor.localIdA03802-
dc.contributor.localIdA03837-
dc.contributor.localIdA00814-
dc.contributor.localIdA02147-
dc.contributor.localIdA04640-
dc.relation.journalcodeJ00992-
dc.identifier.eissn1432-119X-
dc.identifier.pmid22261924-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00418-012-0915-6-
dc.subject.keywordmiR-200b-
dc.subject.keywordZeb1-
dc.subject.keywordZeb2-
dc.subject.keywordE-cadherin-
dc.subject.keywordCell migration-
dc.subject.keywordPalatal fusion-
dc.contributor.alternativeNameKim, Eun Jung-
dc.contributor.alternativeNameNakagawa, Eizo-
dc.contributor.alternativeNameShin, Jeong Oh-
dc.contributor.alternativeNameLee, Jong Min-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.alternativeNameCho, Kyoung Won-
dc.contributor.alternativeNameCho, Sung Won-
dc.contributor.affiliatedAuthorNakagawa, Eizo-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.contributor.affiliatedAuthorCho, Kyoung Won-
dc.contributor.affiliatedAuthorCho, Sung Won-
dc.contributor.affiliatedAuthorKim, Eun Jung-
dc.contributor.affiliatedAuthorShin, Jeong Oh-
dc.contributor.affiliatedAuthorLee, Jong Min-
dc.citation.volume137-
dc.citation.number4-
dc.citation.startPage459-
dc.citation.endPage470-
dc.identifier.bibliographicCitationHISTOCHEMISTRY AND CELL BIOLOGY, Vol.137(4) : 459-470, 2012-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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