Cited 13 times in
The novel function of Oct3/4 in mouse tooth development
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김은정 | - |
dc.contributor.author | 나까가와에이죠 | - |
dc.contributor.author | 신정오 | - |
dc.contributor.author | 정한성 | - |
dc.contributor.author | 조성원 | - |
dc.date.accessioned | 2014-12-19T16:52:54Z | - |
dc.date.available | 2014-12-19T16:52:54Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0948-6143 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90370 | - |
dc.description.abstract | Octamer-binding factor 3/4 (Oct3/4) is one of the key regulators maintaining the pluripotency and self-renewal in embryonic stem cells and is involved in the developmental events. However, the functional significance of Oct3/4 remains to be clarified during tooth morphogenesis. This study aimed to examine the functional role of Oct3/4 in mouse. During tooth morphogenesis (E11-E16.5), Oct3/4-positive cells, detected by nuclear immunoreaction, increased in number, and subsequently, their immunoreaction shifted from the nucleus to the cytoplasm at the stage of cell differentiation (E18.5). Quantitative real-time PCR clearly demonstrated the relationship between isoforms of Oct3/4 and the in vivo cellular localization of Oct3/4, suggesting that the Oct3/4 expressed in nucleus was Oct3/4A, whereas that expressed in the cytoplasm was Oct3/4B. RNAi knockdown of Oct3/4 induced apoptosis and arrested tooth morphogenesis. Our results suggest that (1) the increased number of Oct3/4-positive cells with nuclear immunoreaction correlate with active cell proliferation during tooth morphogenesis and (2) the shift of Oct3/4 from the nucleus to the cytoplasm plays a crucial role in cell differentiation. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | HISTOCHEMISTRY AND CELL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/physiology | - |
dc.subject.MESH | Cell Differentiation/physiology | - |
dc.subject.MESH | Cell Nucleus/metabolism | - |
dc.subject.MESH | Cytoplasm/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Developmental/physiology* | - |
dc.subject.MESH | Gene Knockdown Techniques | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Octamer Transcription Factor-3/genetics* | - |
dc.subject.MESH | Octamer Transcription Factor-3/metabolism | - |
dc.subject.MESH | Odontogenesis/physiology* | - |
dc.subject.MESH | Organ Culture Techniques | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | Tooth*/cytology | - |
dc.subject.MESH | Tooth*/embryology | - |
dc.subject.MESH | Tooth*/physiology | - |
dc.title | The novel function of Oct3/4 in mouse tooth development | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Eizo Nakagawa | - |
dc.contributor.googleauthor | Li Zhang | - |
dc.contributor.googleauthor | Eun-Jung Kim | - |
dc.contributor.googleauthor | Jeong-Oh Shin | - |
dc.contributor.googleauthor | Sung-Won Cho | - |
dc.contributor.googleauthor | Hayato Ohshima | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.identifier.doi | 10.1007/s00418-011-0895-y | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01228 | - |
dc.contributor.localId | A03758 | - |
dc.contributor.localId | A03837 | - |
dc.contributor.localId | A00814 | - |
dc.contributor.localId | A02147 | - |
dc.relation.journalcode | J00992 | - |
dc.identifier.eissn | 1432-119X | - |
dc.identifier.pmid | 22159899 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00418-011-0895-y | - |
dc.subject.keyword | Oct3/4 | - |
dc.subject.keyword | Isoforms | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Tooth morphogenesis | - |
dc.contributor.alternativeName | Kim, Eun Jung | - |
dc.contributor.alternativeName | Nakagawa, Eizo | - |
dc.contributor.alternativeName | Shin, Jeong Oh | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.alternativeName | Cho, Sung Won | - |
dc.contributor.affiliatedAuthor | Nakagawa, Eizo | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Cho, Sung Won | - |
dc.contributor.affiliatedAuthor | Kim, Eun Jung | - |
dc.contributor.affiliatedAuthor | Shin, Jeong Oh | - |
dc.citation.volume | 137 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 367 | - |
dc.citation.endPage | 376 | - |
dc.identifier.bibliographicCitation | HISTOCHEMISTRY AND CELL BIOLOGY, Vol.137(3) : 367-376, 2012 | - |
dc.identifier.rimsid | 34169 | - |
dc.type.rims | ART | - |
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