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Clinical features and prognosis of hepatocellular carcinoma in Mongolia: a multicentre study

Authors
 Oidov Baatarkhuu  ;  Do Young Kim  ;  Pagbajabyn Nymadawa  ;  Seung Up Kim  ;  Kwang-Hyub Han  ;  Jazag Amarsanaa  ;  Dagvasumberel Gonchigsuren  ;  Ravjir Sanduijav  ;  Zundui Lkhagvasuren  ;  Naran Khorolsuren  ;  Ravjir Oyungerel  ;  Sang Hoon Ahn 
Citation
 HEPATOLOGY INTERNATIONAL, Vol.4(6) : 763-769, 2012 
Journal Title
HEPATOLOGY INTERNATIONAL
ISSN
 1936-0533 
Issue Date
2012
Keywords
Hepatocellular carcinoma ; Mongolia ; Survival
Abstract
Purpose: Hepatocellular carcinoma (HCC) is the most common cancer in Mongolia. We aimed to investigate the clinical features, therapeutic modalities, overall survival and prognostic factors for Mongolian patients with HCC.
Method: One hundred ninety-five patients with HCC were consecutively enroled in our study.
Results: The mean age was 61.7 years. The most common etiology for HCC was HCV infection (n = 89, 45.6%), followed by HBV infection (n = 67, 34.4%). The mean tumor diameter was 6.0 ± 2.6 cm. Only 29 (14.9%) patients had a single lesion, while 39 (20.2%) had >3 lesions. Extrahepatic metastasis to lung (n = 23), bone (n = 10) and lymph node (n = 3) were detected in 36 (18.5%) patients. Most patients had advanced HCC—88 (45.1%) in stage III and 57 (29.2%) in stage IV. Surgical resection was performed in 27 (13.8%) patients, RFA in 23 (11.8%) and TACE in 107 (54.9%). When all the patients were categorized as ‘treated’ (n = 156) and ‘not treated’ (n = 39), the 3-year survival was significantly lower in the ‘not treated’ group than in the ‘treated’ group (11 vs. 0%, P < 0.001). Tumor diameter (<3 cm vs. ≥3 cm), extrahepatic metastasis, TNM stage (I/II vs. III/IV) and treatment (or supportive care) were selected as independent predictors for survival.
Conclusions: High proportion of patients with HCC in Mongolia is diagnosed at an advanced stage and survival of these patients is lower compared to other countries. A surveillance system and referral policy for high-risk groups should be urgently established and implemented in Mongolia.
Full Text
http://link.springer.com/article/10.1007%2Fs12072-011-9325-4
DOI
26201525
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90368
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